SCHEMBL6964785

SCHEMBL6964785

O=C(c1cccnc1)[N+]1([O-])CCCCC1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.49
GAA P10253 2/20 0.49
HDAC1 Q13547 1/20 0.49
HDAC6 Q9UBN7 1/20 0.49
APP P05067 1/20 0.49
HCAR3 P49019 1/20 0.49
HCAR2 Q8TDS4 1/20 0.49
KDM4E B2RXH2 1/20 0.48
F7 P08709 1/20 0.47
F3 P13726 1/20 0.47
SARM1 Q6SZW1 1/20 0.47
SIRT2 Q8IXJ6 1/20 0.47
SIRT6 Q8N6T7 1/20 0.47
SIRT1 Q96EB6 1/20 0.47
SIRT3 Q9NTG7 1/20 0.47
SIRT5 Q9NXA8 1/20 0.47
SIRT4 Q9Y6E7 1/20 0.47
THRB P10828 1/20 0.45
LMNA P02545 1/20 0.45
HIF1A Q16665 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6960130 0.81 ALDH1A1 (0.45) ALDH1A1GAAKDM4ELMNASMN1; SMN2
SCHEMBL7338845 0.75 CA2 (0.43) ALDH1A1KDM4ELMNASMN1; SMN2MAPT
Niacinamide SCHEMBL5712752 0.72 F7 (0.88) ALDH1A1GAAHDAC1HDAC6APP
SCHEMBL8676355 0.70 CA1 (0.47) ALDH1A1KDM4ELMNAMAPT
SCHEMBL2784997 0.68 ALDH1A1 (0.71) ALDH1A1GAAHDAC1HDAC6APP
SCHEMBL29915528 0.68 ALDH1A1 (0.71) ALDH1A1GAAHDAC1HDAC6APP
SCHEMBL1242243 0.68 ALDH1A1 (0.71) ALDH1A1GAAHDAC1HDAC6APP
Niacin SCHEMBL23780930 0.67 ALDH1A1 (0.63) ALDH1A1GAAHDAC1HDAC6APP
Niacin SCHEMBL308681 0.67 ALDH1A1 (0.63) ALDH1A1GAAHDAC1HDAC6APP
Niacin SCHEMBL587526 0.67 ALDH1A1 (0.63) ALDH1A1GAAHDAC1HDAC6APP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0787724-B1 NOVEL INTERMEDIATE FOR PRODUCTION AND PROCESS FOR PRODUCING PYRIDINE DERIVATIVE TAIHO PHARMACEUTICAL CO LTD (JP) 2003-04-16 EP disclosed
US-5734059-A Production intermediate and process for producing pyridine derivative TAIHO PHARMACEUTICAL CO., LTD. (JP) 1998-03-31 US disclosed
EP-0787724-A1 NOVEL INTERMEDIATE FOR PRODUCTION AND PROCESS FOR PRODUCING PYRIDINE DERIVATIVE TAIHO PHARMACEUTICAL CO., LTD. (JP) 1997-08-06 EP disclosed