Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.61 |
| ▸ | TCF4 | P15884 | 1/20 | 0.54 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.54 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.50 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.49 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.49 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.45 |
| ▸ | MMP13 | P45452 | 1/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8434488 | 0.82 | IDO1 (0.47) | MAPTALDH1A1CA1CA2CA9 | |
| SCHEMBL8434521 | 0.80 | L3MBTL1 (0.48) | MMP13POLB | |
| SCHEMBL6389243 | 0.79 | LOXL2 (0.60) | MAPTLOXL2CYP4F2CYP4A11MRGPRX4 | |
| SCHEMBL6964968 | 0.78 | BCHE (0.59) | MAPTTCF4CTNNB1LOXL2CYP4F2 | |
| SCHEMBL9432132 | 0.77 | CA9 (0.50) | MAPTCYP2C9ALDH1A1SMN1; SMN2CA12 | |
| SCHEMBL21171359 | 0.77 | MAPT (0.76) | MAPTLOXL2CYP4F2CYP4A11MRGPRX4 | |
| SCHEMBL29768576 | 0.75 | CYP4F2 (0.58) | MAPTTCF4CTNNB1LOXL2CYP4F2 | |
| SCHEMBL8872453 | 0.75 | CA12 (0.59) | MAPTTCF4CTNNB1CYP2C9CA12 | |
| SCHEMBL29084501 | 0.75 | CYP4F2 (0.58) | MAPTTCF4CTNNB1LOXL2CYP4F2 | |
| SCHEMBL6959194 | 0.75 | CA2 (0.59) | MAPTCYP2C9ALDH1A1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729465-B1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE DAVIS & CO (US) | 2003-01-22 | — | — | EP | disclosed |
| US-6005103-A | TREATMENT OF BACTERIAL AND VIRAL INFECTIONS AND DISEASES, INCLUDING AIDS | WARNER-LAMBERT COMPANY (US) | 1999-12-21 | — | — | US | disclosed |