Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 2/20 | 0.43 |
| ▸ | CCRL2 | O00421 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | TRPC6 | Q9Y210 | 3/20 | 0.39 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6961572 | 0.90 | KDM1A (0.43) | ADRA1ACCRL2CCR2KCNH2TRPC6 | |
| Hydrochloric Acid SCHEMBL7955138 | 0.90 | KDM1A (0.43) | ADRA1ACCRL2CCR2KCNH2TRPC6 | |
| SCHEMBL6964976 | 0.85 | KDM4E (0.44) | ADRA1ACCRL2CCR2KCNH2MGLL | |
| SCHEMBL7707804 | 0.85 | CCRL2 (0.41) | ADRA1ACCRL2CCR2KCNH2MGLL | |
| SCHEMBL7707353 | 0.85 | CCRL2 (0.41) | ADRA1ACCRL2CCR2KCNH2MGLL | |
| Hydrochloric Acid SCHEMBL6956254 | 0.83 | KDM4E (0.43) | ADRA1ACCRL2CCR2KCNH2MGLL | |
| Hydrochloric Acid SCHEMBL6956256 | 0.83 | CCRL2 (0.40) | ADRA1ACCRL2CCR2KCNH2MGLL | |
| SCHEMBL29580963 | 0.80 | ADRA1A (0.49) | ADRA1APROKR1DRD4HCRTR2 | |
| SCHEMBL3167985 | 0.80 | ADRA1A (0.49) | ADRA1APROKR1DRD4HCRTR2 | |
| SCHEMBL7968202 | 0.77 | ADRA1A (0.36) | ADRA1ACCRL2CCR2KCNH2MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0998285-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 2003-01-08 | — | — | EP | disclosed |
| US-6255315-B1 | BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., INC. | 2001-07-03 | — | — | US | disclosed |
| EP-0998285-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 2000-05-10 | — | — | EP | disclosed |
| US-6037354-A | ADMINISTERING PHENYL-SUBSTITUTED THIAZOLIDIN-4-ONE OR OXAZOLIDIN-2-ONE DERIVATIVE TO TREAT BENIGN PROSTATE HYPERPLASIA; SIDE EFFECT REDUCTION | MERCK & CO., INC. (US) | 2000-03-14 | — | — | US | disclosed |
| WO-1998057641-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-12-23 | — | — | WO | disclosed |