Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 2/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | CCRL2 | O00421 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 4/20 | 0.35 |
| ▸ | MGLL | Q99685 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8006278 | 0.81 | GRM5 (0.41) | ADRA1ADRD4KDM4EALDH1A1 | |
| SCHEMBL7968198 | 0.81 | DRD4 (0.40) | ADRA1ADRD4CCRL2CCR2KCNH2 | |
| SCHEMBL7707804 | 0.79 | CCRL2 (0.41) | ADRA1ADRD4CCRL2CCR2KCNH2 | |
| SCHEMBL7707353 | 0.79 | CCRL2 (0.41) | ADRA1ADRD4CCRL2CCR2KCNH2 | |
| Hydrochloric Acid SCHEMBL6956256 | 0.78 | CCRL2 (0.40) | ADRA1ADRD4CCRL2CCR2KCNH2 | |
| SCHEMBL6964977 | 0.77 | ADRA1A (0.43) | ADRA1ADRD4CCRL2CCR2KCNH2 | |
| SCHEMBL3167985 | 0.75 | ADRA1A (0.49) | ADRA1ADRD4GRM2HCRTR2PROKR1 | |
| SCHEMBL29580963 | 0.75 | ADRA1A (0.49) | ADRA1ADRD4GRM2HCRTR2PROKR1 | |
| Hydrochloric Acid SCHEMBL7955138 | 0.74 | KDM1A (0.43) | ADRA1ADRD4CCRL2CCR2KCNH2 | |
| SCHEMBL6964976 | 0.74 | KDM4E (0.44) | ADRA1ADRD4CCRL2CCR2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6255315-B1 | BENIGN PROSTATIC HYPERPLASIA | MERCK & CO., INC. | 2001-07-03 | — | — | US | disclosed |
| US-6037354-A | ADMINISTERING PHENYL-SUBSTITUTED THIAZOLIDIN-4-ONE OR OXAZOLIDIN-2-ONE DERIVATIVE TO TREAT BENIGN PROSTATE HYPERPLASIA; SIDE EFFECT REDUCTION | MERCK & CO., INC. (US) | 2000-03-14 | — | — | US | disclosed |