Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 4/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.47 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.47 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.47 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5200635 | 0.98 | ALDH1A1 (0.49) | CHRM2CHRM1CHRM4CHRM5CHRM3 | |
| SCHEMBL7266907 | 0.90 | CHRM1 (0.49) | CHRM2CHRM1CHRM4CHRM3 | |
| SCHEMBL10369501 | 0.89 | CHRM1 (0.51) | CHRM2CHRM1CHRM4CHRM3 | |
| Hydrochloric Acid SCHEMBL11442910 | 0.86 | ALDH1A1 (0.40) | CHRM2CHRM1CHRM4CHRM5CHRM3 | |
| Oxalic Acid SCHEMBL10367531 | 0.85 | CHRM1 (0.45) | CHRM2CHRM1CHRM4CHRM3 | |
| SCHEMBL9696817 | 0.79 | ALDH1A1 (0.46) | CHRM2CHRM1CHRM4CHRM5CHRM3 | |
| SCHEMBL3314224 | 0.79 | CHRM1 (0.40) | CHRM2CHRM1CHRM4CHRM3 | |
| Hydrochloric Acid SCHEMBL4322280 | 0.78 | ALDH1A1 (0.45) | CHRM2CHRM1CHRM4CHRM5CHRM3 | |
| SCHEMBL8872327 | 0.78 | SLC6A2 (0.36) | CHRM1 | |
| SCHEMBL9967271 | 0.77 | CHRM2 (0.52) | CHRM2CHRM1CHRM4CHRM5CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4925942-A | Preparation of quinuclidine-3-methanol | RUTGERSWERKE AG (DE) | 1990-05-15 | — | — | US | claimed |
| US-6613791-B1 | Treating migraine, neurogenic inflammation, rheumatoid arthritis or insulin resistance | NOVO NORDISK A/S (DK) | 2003-09-02 | — | — | US | disclosed |
| EP-0820451-B1 | NOVEL HETEROCYCLIC COMPOUNDS | NOVO NORDISK AS (DK) | 2003-01-15 | — | — | EP | disclosed |
| EP-1098883-A4 | PROCESS FOR PREPARING HETEROCYCLIC COMPOUNDS | LILLY CO ELI (US) | 2001-11-14 | — | — | EP | disclosed |
| US-6239148-B1 | TREATMENT OF PAINFUL, HYPERALGESIC AND/OR INFLAMMATORY CONDITIONS IN WHICH C-FIBERS PLAY A ROLE BY ELICITING NEUROGENIC PAIN, INSULIN RESISTANCE IN DIABETES MELLITUS OR AGING, INHIBIT INSULIN ANTAGONIZING PEPTIDE, | NOVO NORDISK A/S (DK) | 2001-05-29 | — | — | US | disclosed |
| EP-1098883-A1 | PROCESS FOR PREPARING HETEROCYCLIC COMPOUNDS | ELI LILLY AND COMPANY (US) | 2001-05-16 | — | — | EP | disclosed |
| US-6166009-A | N-substituted azaheterocyclic carboxylic acids and esters thereof | NOVO NORDISK A/S (DK) | 2000-12-26 | — | — | US | disclosed |
| US-6110913-A | ANTIINFLAMMATORY AGENTS, ANALGESICS | NOVO NORDISK A/S (DK) | 2000-08-29 | — | — | US | disclosed |
| US-6071901-A | TREATING PAIN, HYPERALGESIA AND/OR INFLAMMATORY CONDITIONS IN WHICH C-FIBERS PLAY A PATHOPHYSIOLOGICAL ROLE; INHIBITION OF NEUROGENIC INFLAMMATION INVOLVING THE RELEASE OF NEURO-PEPTIDE FROM PERIPHERAL AND CENTRAL ENDINGS OF SENSORY NERVES | NOVO NORDISK A/S (DK) | 2000-06-06 | — | — | US | disclosed |
| US-5874428-A | A DRUG TREATING DIABETIC NEUROPATHY, MIGRAINE, NEUROGENIC INFLAMMATION OR RHEUMATOID ARTHRITIS | NOVO NORDISK ALS (DK) | 1999-02-23 | — | — | US | disclosed |
| EP-0328200-A1 | Five-membered ring systems with bonded azacyclic ring substituents | MERCK SHARP & DOHME LTD. (GB) | 1989-08-16 | — | — | EP | disclosed |
| EP-0327155-A2 | Pyrazines, pyrimidines and pyridazines, useful in the treatment of senile dementia | MERCK SHARP & DOHME LTD. (GB) | 1989-08-09 | — | — | EP | disclosed |
| EP-0323864-A2 | Lipophilic oxadiazoles | MERCK SHARP & DOHME LTD. (GB) | 1989-07-12 | — | — | EP | disclosed |
| EP-0316718-A2 | Azacyclic compounds and their preparation and use | NOVO NORDISK A/S (DK) | 1989-05-24 | — | — | EP | disclosed |
| EP-0307142-A1 | Thiadiazoles useful in the treatment of senile dementia | MERCK SHARP & DOHME LTD. (GB) | 1989-03-15 | — | — | EP | disclosed |
| EP-0307141-A2 | Oxazoles and thiazoles for the treatment of senile dementia | MERCK SHARP & DOHME LTD. (GB) | 1989-03-15 | — | — | EP | disclosed |
| EP-0261763-A1 | Novel bridged bicyclic N-heterocycles | BEECHAM GROUP PLC (GB) | 1988-03-30 | — | — | EP | disclosed |
| EP-0239309-A2 | Oxadiazoles useful in the treatment of senile dementia | MERCK SHARP & DOHME LTD. (GB) | 1987-09-30 | — | — | EP | disclosed |
| US-4292190-A | ANTIFREEZES FOR COOLING SYSTEMS OF INTERNAL COMBUSTION ENGINES | BASF WYANDOTTE CORPORATION (US) | 1981-09-29 | — | — | US | disclosed |
| EP-0015002-A1 | 1-substituted imidazoles, and salts thereof, a method for their preparation and pharmaceutical formulations thereof | THE WELLCOME FOUNDATION LIMITED (GB) | 1980-09-03 | — | — | EP | disclosed |