Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 3/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10369501 | 0.98 | CHRM1 (0.51) | CHRM1CHRM2CHRM4CHRM3 | |
| Oxalic Acid SCHEMBL10367531 | 0.95 | CHRM1 (0.45) | CHRM1CHRM2CHRM4CHRM3 | |
| SCHEMBL6965129 | 0.90 | CHRM2 (0.47) | CHRM1CHRM2CHRM4CHRM3 | |
| SCHEMBL3314224 | 0.89 | CHRM1 (0.40) | CHRM1CHRM2CHRM4CHRM3 | |
| Hydrochloric Acid SCHEMBL5200635 | 0.89 | ALDH1A1 (0.49) | CHRM1CHRM2CHRM4CHRM3 | |
| SCHEMBL10368013 | 0.81 | CHRM2 (0.41) | CHRM1CHRM2CHRM4CHRM3 | |
| SCHEMBL7330432 | 0.80 | CHRM1 (0.42) | CHRM1CHRM2CHRM4CHRM3 | |
| SCHEMBL8935492 | 0.78 | CHRM2 (0.46) | CHRM1CHRM2CHRM4CHRM3 | |
| Hydrochloric Acid SCHEMBL11442910 | 0.77 | ALDH1A1 (0.40) | CHRM1CHRM2CHRM4CHRM3 | |
| SCHEMBL8872327 | 0.77 | SLC6A2 (0.36) | CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116964048-A | Bicyclic tetrahydroazepine derivatives for the treatment of cancer | 豪夫迈·罗氏有限公司 | 2023-10-27 | — | — | CN | claimed |
| US-4870081-A | DEMENTIA | BEECHAM GROUP P.L.C. (GB) | 1989-09-26 | — | — | US | claimed |
| US-5405853-A | Potent muscarinic agonists having good central nervous system penetrability | MERCK SHARPE & DOHME LTD. (GB) | 1995-04-11 | — | — | US | disclosed |
| EP-0307142-B1 | Thiadiazoles useful in the treatment of senile dementia | MERCK SHARP & DOHME (GB) | 1994-09-14 | — | — | EP | disclosed |
| EP-0261763-B1 | Novel bridged bicyclic N-heterocycles | BEECHAM GROUP PLC (GB) | 1994-02-09 | — | — | EP | disclosed |
| EP-0328200-B1 | Five-membered ring systems with bonded azacyclic ring substituents | MERCK SHARP & DOHME (GB) | 1993-12-08 | — | — | EP | disclosed |
| US-5244906-A | Miticides for rice | DOWELANCO (US) | 1993-09-14 | — | — | US | disclosed |
| US-5041456-A | Pharmaceutically useful 3-(indol-3-yl)-1,2,4-oxa- and thiadiazoles substituted in the 5-position by an amino containing group | MERCK SHARP & DOHME LTD. (GB) | 1991-08-20 | — | — | US | disclosed |
| EP-0398617-A2 | Process for resolving 1-azabicyclo [2.2.1]heptane-3-carboxylates | MERCK SHARP & DOHME LTD. (GB) | 1990-11-22 | — | — | EP | disclosed |
| US-4968691-A | TREATMENT AND PREVENTION OF DEMENTIA | BEECHAM GROUP P.L.C. (GB) | 1990-11-06 | — | — | US | disclosed |
| US-4952587-A | PSYCHOLOGICAL DISORDERS, MIGRAINES, ALZHEIMER*S | MERCK SHARP & DOHME LTD. (GB) | 1990-08-28 | — | — | US | disclosed |
| EP-0328200-A1 | Five-membered ring systems with bonded azacyclic ring substituents | MERCK SHARP & DOHME LTD. (GB) | 1989-08-16 | — | — | EP | disclosed |
| EP-0323864-A2 | Lipophilic oxadiazoles | MERCK SHARP & DOHME LTD. (GB) | 1989-07-12 | — | — | EP | disclosed |
| EP-0307142-A1 | Thiadiazoles useful in the treatment of senile dementia | MERCK SHARP & DOHME LTD. (GB) | 1989-03-15 | — | — | EP | disclosed |
| EP-0261763-A1 | Novel bridged bicyclic N-heterocycles | BEECHAM GROUP PLC (GB) | 1988-03-30 | — | — | EP | disclosed |