Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9369836 | 0.84 | TSHR (0.35) | SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL18648496 | 0.80 | ALDH1A1 (0.35) | CHRM1 | |
| SCHEMBL6965129 | 0.78 | CHRM2 (0.47) | CHRM1 | |
| SCHEMBL7266907 | 0.77 | CHRM1 (0.49) | CHRM1 | |
| Hydrochloric Acid SCHEMBL5200635 | 0.77 | ALDH1A1 (0.49) | CHRM1 | |
| SCHEMBL10369501 | 0.75 | CHRM1 (0.51) | CHRM1 | |
| Oxalic Acid SCHEMBL10367531 | 0.72 | CHRM1 (0.45) | SLC6A2SLC6A4SLC6A3CHRM1 | |
| SCHEMBL3314224 | 0.70 | CHRM1 (0.40) | CHRM1 | |
| SCHEMBL14256081 | 0.68 | SLC6A2 (0.55) | SLC6A2SLC6A4SLC6A3 | |
| Hydrochloric Acid SCHEMBL11442910 | 0.67 | ALDH1A1 (0.40) | CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5686463-A | Oxadiazoles useful in the treatment of senile dementia | MERCK, SHARP & DOHME, LTD. (GB) | 1997-11-11 | — | — | US | disclosed |
| EP-0239309-B1 | Oxadiazoles useful in the treatment of senile dementia | MERCK SHARP & DOHME (GB) | 1994-01-12 | — | — | EP | disclosed |
| EP-0239309-A2 | Oxadiazoles useful in the treatment of senile dementia | MERCK SHARP & DOHME LTD. (GB) | 1987-09-30 | — | — | EP | disclosed |