Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 7/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8337032 | 0.88 | MEN1 (0.41) | ABCB1MAPTSMN1; SMN2HTT | |
| SCHEMBL6965271 | 0.84 | HTR1A (0.48) | ABCB1MAPT | |
| SCHEMBL8341092 | 0.83 | DRD2 (0.43) | ABCB1MAPTSMN1; SMN2HTT | |
| SCHEMBL6839501 | 0.76 | HTR1A (0.48) | SLC6A2HTR2ASLC6A4SLC6A3 | |
| SCHEMBL27464076 | 0.76 | ABCB1 (0.47) | ABCB1MAPTSMN1; SMN2 | |
| SCHEMBL8337660 | 0.74 | DRD4 (0.43) | MAPT | |
| SCHEMBL6839523 | 0.74 | MAPT (0.57) | ABCB1MAPTSMN1; SMN2HTT | |
| SCHEMBL6965306 | 0.72 | HTR1A (0.43) | MAPT | |
| SCHEMBL8340386 | 0.70 | HTR7 (0.57) | HTR2ASLC6A4 | |
| SCHEMBL8339768 | 0.69 | KMT2A (0.41) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0775118-B1 | BENZIMIDAZOLE DERIVATIVES HAVING DOPAMINERGIC ACTIVITY | PFIZER (US) | 2003-06-04 | — | — | EP | disclosed |
| US-5889010-A | PSYCHOLOGICAL DISORDERS; UROGENITAL DISORDERS; COGNITION ACTIVATORS; NERVOUS SYSTEM DISORDERS; VISION DEFECTS; CONGESTIVE HEART FAILURE; DRUG ABRUSE; PARKINSON'S DISEASE;ANTIINFLAMMATORY AGENTS; ANTIALLERGENS | PFIZER INC. (US) | 1999-03-30 | — | — | US | disclosed |
| EP-0775118-A1 | BENZIMIDAZOLE DERIVATIVES HAVING DOPAMINERGIC ACTIVITY | PFIZER INC. (US) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996004250-A1 | BENZIMIDAZOLE DERIVATIVES HAVING DOPAMINERGIC ACTIVITY | PFIZER INC. (US) | 1996-02-15 | — | — | WO | disclosed |