Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 5/20 | 0.57 |
| ▸ | HTR1A | P08908 | 5/20 | 0.57 |
| ▸ | DRD3 | P35462 | 3/20 | 0.51 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | MPO | P05164 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6839501 | 0.93 | HTR1A (0.48) | HTR7HTR1AHTR2ASLC6A4 | |
| SCHEMBL8336417 | 0.87 | HTR3E (0.53) | HTR1AP2RX7SIGMAR1 | |
| SCHEMBL7081243 | 0.86 | HTR7 (0.67) | HTR7HTR1ADRD3P2RX7DRD2 | |
| SCHEMBL15748179 | 0.86 | HTR7 (0.55) | HTR7HTR1ADRD3P2RX7DRD2 | |
| SCHEMBL8336244 | 0.83 | SIGMAR1 (0.52) | HTR1ADRD2SIGMAR1 | |
| SCHEMBL8788615 | 0.80 | GRM2 (0.42) | HTR7HTR1ADRD3P2RX7DRD2 | |
| SCHEMBL8788970 | 0.79 | MCHR1 (0.48) | HTR1ADRD3DRD2HTR2ASIGMAR1 | |
| SCHEMBL8336401 | 0.78 | PKM (0.47) | HTR1ADRD3DRD2HTR2ASLC6A4 | |
| SCHEMBL17192201 | 0.76 | KCNH2 (0.64) | HTR7HTR1ADRD3P2RX7DRD2 | |
| SCHEMBL9053834 | 0.76 | DRD2 (0.50) | HTR7HTR1ADRD3DRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5889010-A | PSYCHOLOGICAL DISORDERS; UROGENITAL DISORDERS; COGNITION ACTIVATORS; NERVOUS SYSTEM DISORDERS; VISION DEFECTS; CONGESTIVE HEART FAILURE; DRUG ABRUSE; PARKINSON'S DISEASE;ANTIINFLAMMATORY AGENTS; ANTIALLERGENS | PFIZER INC. (US) | 1999-03-30 | — | — | US | disclosed |
| EP-0775118-A1 | BENZIMIDAZOLE DERIVATIVES HAVING DOPAMINERGIC ACTIVITY | PFIZER INC. (US) | 1997-05-28 | — | — | EP | disclosed |
| WO-1996004250-A1 | BENZIMIDAZOLE DERIVATIVES HAVING DOPAMINERGIC ACTIVITY | PFIZER INC. (US) | 1996-02-15 | — | — | WO | disclosed |