Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UCHL1 | P09936 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.31 |
| ▸ | ANPEP | P15144 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15200625 | 0.84 | CYP1A2 (0.43) | UCHL1CHRM2CHRM1CHRM3NR1H2 | |
| SCHEMBL695599 | 0.84 | CYP1A2 (0.43) | UCHL1CHRM2CHRM1CHRM3NR1H2 | |
| SCHEMBL8212932 | 0.79 | UCHL1 (0.42) | UCHL1CHRM2CHRM1CHRM3NR1H2 | |
| SCHEMBL695593 | 0.78 | MEN1 (0.33) | UCHL1NR1H2USP30MEN1ALDH1A1 | |
| SCHEMBL3382551 | 0.78 | HSD17B10 (0.38) | UCHL1CHRM2CHRM1CHRM3NR1H2 | |
| SCHEMBL7143154 | 0.78 | HSD17B10 (0.38) | UCHL1CHRM2CHRM1CHRM3NR1H2 | |
| SCHEMBL8607697 | 0.78 | MMP2 (0.40) | UCHL1CHRM2CHRM1CHRM3NR1H2 | |
| SCHEMBL19910775 | 0.78 | CHRM2 (0.37) | UCHL1CHRM2CHRM1CHRM3NR1H2 | |
| SCHEMBL4418512 | 0.78 | HSD17B10 (0.38) | UCHL1CHRM2CHRM1CHRM3NR1H2 | |
| SCHEMBL8609251 | 0.78 | MMP2 (0.40) | UCHL1CHRM2CHRM1CHRM3NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421826-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2012-02-29 | — | — | EP | disclosed |
| WO-2010121918-A1 | PROLINE DERIVATIVES AS CATHEPSIN INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2010-10-28 | — | — | WO | disclosed |