Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UCHL1 | P09936 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | ANPEP | P15144 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 3/20 | 0.33 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.31 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.31 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18538108 | 0.86 | UCHL1 (0.53) | UCHL1NR1H2CYP1A2POLBCYP3A4 | |
| SCHEMBL30501862 | 0.86 | UCHL1 (0.53) | UCHL1NR1H2CYP1A2POLBCYP3A4 | |
| SCHEMBL27393752 | 0.86 | UCHL1 (0.53) | UCHL1NR1H2CYP1A2POLBCYP3A4 | |
| SCHEMBL25619159 | 0.86 | UCHL1 (0.53) | UCHL1NR1H2CYP1A2POLBCYP3A4 | |
| SCHEMBL31340923 | 0.86 | UCHL1 (0.53) | UCHL1NR1H2CYP1A2POLBCYP3A4 | |
| SCHEMBL18577225 | 0.85 | UCHL1 (0.45) | UCHL1NR1H2CYP1A2POLBCYP3A4 | |
| SCHEMBL18577227 | 0.85 | UCHL1 (0.45) | UCHL1NR1H2CYP1A2POLBCYP3A4 | |
| SCHEMBL7805563 | 0.83 | MMP2 (0.48) | UCHL1MMP2ANPEPNR1H2NR1H3 | |
| SCHEMBL5691732 | 0.83 | MMP2 (0.48) | UCHL1MMP2ANPEPNR1H2NR1H3 | |
| SCHEMBL489252 | 0.83 | MMP2 (0.48) | UCHL1MMP2ANPEPNR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054865-A1 | FARNESYL TRANSFERASE INHIBITORS | AstraZeneca UK Limited (GB) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999041235-A1 | FARNESYL TRANSFERASE INHIBITORS | ASTRAZENECA UK LIMITED (GB) | 1999-08-19 | — | — | WO | disclosed |