Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | TSPO | P30536 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7157384 | 0.86 | MAPT (0.56) | LMNAALDH1A1SMN1; SMN2KDM4ETSPO | |
| SCHEMBL9442052 | 0.85 | L3MBTL1 (0.52) | LMNAALDH1A1TSPOTP53HTT | |
| SCHEMBL13044291 | 0.85 | SGMS2 (0.55) | LMNAALDH1A1SMN1; SMN2KDM4EHTT | |
| SCHEMBL7820020 | 0.85 | HTT (0.64) | LMNAALDH1A1KDM4ETSPOTP53 | |
| SCHEMBL9126601 | 0.84 | ALDH1A1 (0.58) | LMNAALDH1A1SMN1; SMN2TSPOTP53 | |
| SCHEMBL14648839 | 0.83 | LMNA (0.58) | LMNAALDH1A1SMN1; SMN2KDM4EHTT | |
| SCHEMBL6447237 | 0.81 | ALDH1A1 (0.68) | LMNAALDH1A1SMN1; SMN2KDM4ETP53 | |
| SCHEMBL14691336 | 0.81 | ALDH1A1 (0.50) | LMNAALDH1A1SMN1; SMN2TSPOTP53 | |
| SCHEMBL8278415 | 0.80 | TP53 (0.61) | LMNAALDH1A1SMN1; SMN2KDM4ETP53 | |
| SCHEMBL31123658 | 0.80 | ALDH1A1 (0.60) | LMNAALDH1A1SMN1; SMN2KDM4ETSPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729465-B1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE DAVIS & CO (US) | 2003-01-22 | — | — | EP | disclosed |
| US-6005103-A | TREATMENT OF BACTERIAL AND VIRAL INFECTIONS AND DISEASES, INCLUDING AIDS | WARNER-LAMBERT COMPANY (US) | 1999-12-21 | — | — | US | disclosed |
| EP-0729465-A1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1996-09-04 | — | — | EP | disclosed |
| WO-1995014013-A1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1995-05-26 | — | — | WO | disclosed |