Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOS1 | Q07889 | 2/20 | 0.41 |
| ▸ | PLK1 | P53350 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.39 |
| ▸ | VNN1 | O95497 | 5/20 | 0.37 |
| ▸ | PDE9A | O76083 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.36 |
| ▸ | BCDIN3D | Q7Z5W3 | 2/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.34 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6955432 | 0.80 | MAPT (0.46) | ALDH1A1MAPTVNN1PDE9AJAK2 | |
| SCHEMBL6955428 | 0.71 | ALDH1A1 (0.47) | ALDH1A1MAPTCREBBPCYP11B2 | |
| SCHEMBL6969069 | 0.71 | ALDH1A1 (0.41) | ALDH1A1MAPT | |
| SCHEMBL6971588 | 0.68 | PDE9A (0.47) | ALDH1A1MAPTVNN1PDE9AJAK2 | |
| SCHEMBL6967041 | 0.68 | ALDH1A1 (0.45) | ALDH1A1MAPTPDE9ACREBBPCYP11B2 | |
| SCHEMBL6967044 | 0.67 | MAPT (0.45) | ALDH1A1MAPTPDE9ACREBBPCYP11B2 | |
| SCHEMBL13075567 | 0.67 | LRRK2 (0.44) | SOS1LRRK2PFKFB3VNN1S1PR1 | |
| SCHEMBL319805 | 0.67 | LRRK2 (0.44) | SOS1LRRK2PFKFB3VNN1S1PR1 | |
| SCHEMBL25627919 | 0.66 | S1PR1 (0.44) | LRRK2S1PR1GPR139NAMPT | |
| SCHEMBL6972441 | 0.65 | ALDH1A1 (0.43) | ALDH1A1MAPTVNN1CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | disclosed |