Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 7/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 7/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SETDB1 | Q15047 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7084970 | 0.89 | MAPT (0.37) | SMN1; SMN2MAPTMEN1CYP1A2CYP2C9 | |
| SCHEMBL6974325 | 0.87 | TP53 (0.39) | MTNR1AMTNR1BL3MBTL1NPSR1MAPT | |
| SCHEMBL6966537 | 0.87 | NPSR1 (0.36) | SMN1; SMN2MTNR1AMTNR1BL3MBTL1NPSR1 | |
| SCHEMBL7084307 | 0.86 | SMN1; SMN2 (0.44) | SMN1; SMN2MTNR1AMTNR1BL3MBTL1NPSR1 | |
| SCHEMBL6974787 | 0.85 | SMN1; SMN2 (0.35) | SMN1; SMN2MAPTKDM4ENPC1RAB9A | |
| SCHEMBL6965470 | 0.83 | SETDB1 (0.33) | SMN1; SMN2L3MBTL1NPSR1POLBSETDB1 | |
| SCHEMBL6961581 | 0.83 | SMN1; SMN2 (0.32) | SMN1; SMN2L3MBTL1NPSR1MAPTNPC1 | |
| SCHEMBL6972012 | 0.83 | RAB9A (0.41) | SMN1; SMN2L3MBTL1MAPTMEN1CYP2C9 | |
| SCHEMBL6966247 | 0.82 | CYP1A2 (0.49) | SMN1; SMN2L3MBTL1MAPTMEN1CYP1A2 | |
| SCHEMBL6970053 | 0.82 | PTPN1 (0.34) | SMN1; SMN2MAPTKDM4EPOLBSETDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |