Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | TOP2A | P11388 | 1/20 | 0.31 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.30 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.30 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7086333 | 0.91 | CYP1A2 (0.39) | TSHRATMMEN1CYP1A2CYP2C9 | |
| SCHEMBL7081165 | 0.91 | LMNA (0.35) | LMNATSHRATMSMN1; SMN2MEN1 | |
| SCHEMBL7084632 | 0.91 | SMN1; SMN2 (0.36) | TSHRATMSMN1; SMN2MEN1CYP1A2 | |
| SCHEMBL6968991 | 0.89 | LMNA (0.41) | LMNATSHRATMMEN1CYP1A2 | |
| SCHEMBL7081807 | 0.89 | ALOX12 (0.35) | LMNASMN1; SMN2TP53 | |
| SCHEMBL7087212 | 0.89 | EPHX1 (0.33) | LMNAMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL6960266 | 0.88 | CYP1A2 (0.36) | LMNASMN1; SMN2MEN1CYP1A2CYP2C9 | |
| SCHEMBL7084824 | 0.87 | PIM1 (0.34) | LMNATSHRSMN1; SMN2MEN1CYP1A2 | |
| SCHEMBL6965379 | 0.86 | CYP2C9 (0.36) | LMNATSHRSMN1; SMN2MEN1CYP1A2 | |
| SCHEMBL6961556 | 0.86 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |