SCHEMBL6965629

SCHEMBL6965629

CCCn1c(COCc2ccc(OC)cc2)nc(C(C)C)c1Sc1cc(Cl)cc(Cl)c1

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHFR P00374 1/20 0.33
DHODH Q02127 1/20 0.32
GAA P10253 2/20 0.32
TP53 P04637 2/20 0.32
MAPT P10636 2/20 0.32
SMN1; SMN2 Q16637 2/20 0.32
PDE1A P54750 2/20 0.31
PDE1B Q01064 2/20 0.31
PDE1C Q14123 2/20 0.31
TRPV6 Q9H1D0 1/20 0.31
CCR2 P41597 1/20 0.31
ALDH1A1 P00352 2/20 0.31
NPSR1 Q6W5P4 2/20 0.31
DCTPP1 Q9H773 1/20 0.31
KDM4E B2RXH2 1/20 0.31
LMNA P02545 1/20 0.31
TSHR P16473 1/20 0.31
ADORA3 P0DMS8 1/20 0.31
ADORA1 P30542 1/20 0.31
HRH4 Q9H3N8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6967218 0.93 MAPT (0.35) DHFRDHODHTP53MAPTSMN1; SMN2
SCHEMBL6974229 0.92 MAPT (0.34) DHFRDHODHGAATP53MAPT
SCHEMBL6964520 0.88 DHODH (0.34) DHFRDHODHGAATP53MAPT
SCHEMBL14439857 0.88 DHODH (0.39) DHODHGAATP53MAPTSMN1; SMN2
SCHEMBL6957630 0.88 DHODH (0.39) DHODHGAATP53MAPTSMN1; SMN2
SCHEMBL6963914 0.87 NPC1 (0.38) DHODHGAATP53MAPTSMN1; SMN2
SCHEMBL6958208 0.87 MAPT (0.32) DHODHGAATP53MAPTSMN1; SMN2
SCHEMBL6969562 0.86 CCR2 (0.35) DHODHMAPTSMN1; SMN2CCR2ALDH1A1
SCHEMBL14459507 0.86 P2RX3 (0.35) GAATP53MAPTSMN1; SMN2CCR2
SCHEMBL6974459 0.85 HRH1 (0.37) GAATP53MAPTSMN1; SMN2LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786455-B1 IMIDAZOLE DERIVATIVE SHIONOGI & CO (JP) 2003-12-03 EP claimed
EP-0786455-B1 IMIDAZOLE DERIVATIVE SHIONOGI & CO (JP) 2003-12-03 EP disclosed
US-6147097-A METHOD FOR TREATING AIDS SHIONOGI & CO., LTD. (JP) 2000-11-14 US disclosed
US-5910506-A IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC SHIONOGI & CO., LTD. (JP) 1999-06-08 US disclosed
EP-0786455-A1 IMIDAZOLE DERIVATIVE SHIONOGI & CO., LTD. (JP) 1997-07-30 EP disclosed