Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 6/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | CDC25A | P30304 | 2/20 | 0.36 |
| ▸ | CDC25B | P30305 | 2/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | EDNRB | P24530 | 1/20 | 0.34 |
| ▸ | EDNRA | P25101 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6957630 | 1.00 | DHODH (0.39) | DHODHTP53MAPTSMN1; SMN2GAA | |
| SCHEMBL14439828 | 0.93 | TDP1 (0.40) | DHODHTP53MAPTSMN1; SMN2TDP1 | |
| SCHEMBL6973428 | 0.91 | GABRA1 (0.36) | DHODHTP53MAPTSMN1; SMN2GAA | |
| SCHEMBL6974229 | 0.90 | MAPT (0.34) | DHODHTP53MAPTSMN1; SMN2GAA | |
| SCHEMBL5853114 | 0.89 | TDP1 (0.37) | DHODHTP53MAPTTDP1ALDH1A1 | |
| SCHEMBL6960939 | 0.89 | TP53 (0.35) | TP53MAPTTDP1 | |
| SCHEMBL6965629 | 0.88 | DHFR (0.33) | DHODHTP53MAPTSMN1; SMN2GAA | |
| SCHEMBL6962510 | 0.87 | MAPT (0.39) | DHODHMAPTTDP1CCR2CDC25A | |
| SCHEMBL14459507 | 0.87 | P2RX3 (0.35) | TP53MAPTSMN1; SMN2GAACCR2 | |
| SCHEMBL6966496 | 0.86 | VCP (0.37) | DHODHTP53MAPTSMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070190523-A1 | Method and compositions for identifying anti-hiv therapeutic compounds | GILEAD SCIENCES, INC. | 2007-08-16 | — | — | US | disclosed |