Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 5/20 | 0.55 |
| ▸ | HTR2A | P28223 | 4/20 | 0.55 |
| ▸ | HTR2C | P28335 | 3/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.55 |
| ▸ | HTR5A | P47898 | 11/20 | 0.53 |
| ▸ | HTR1D | P28221 | 8/20 | 0.53 |
| ▸ | HTR1B | P28222 | 6/20 | 0.53 |
| ▸ | MPO | P05164 | 1/20 | 0.52 |
| ▸ | HTR2B | P41595 | 3/20 | 0.50 |
| ▸ | HTR3E | A5X5Y0 | 2/20 | 0.50 |
| ▸ | HTR3B | O95264 | 2/20 | 0.50 |
| ▸ | HTR1E | P28566 | 2/20 | 0.50 |
| ▸ | HTR1F | P30939 | 2/20 | 0.50 |
| ▸ | HTR7 | P34969 | 2/20 | 0.50 |
| ▸ | HTR3A | P46098 | 2/20 | 0.50 |
| ▸ | HTR6 | P50406 | 2/20 | 0.50 |
| ▸ | HTR4 | Q13639 | 2/20 | 0.50 |
| ▸ | HTR3D | Q70Z44 | 2/20 | 0.50 |
| ▸ | HTR3C | Q8WXA8 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6965407 | 0.85 | HTR1A (0.56) | HTR1AHTR2AHTR2CSLC6A4HTR5A | |
| SCHEMBL6967767 | 0.84 | HTR1D (0.59) | HTR2AHTR1DHTR1BMPO | |
| SCHEMBL6965686 | 0.83 | HTR1A (0.54) | HTR1AHTR2AHTR2CSLC6A4HTR5A | |
| SCHEMBL7005001 | 0.81 | HTR1A (0.47) | HTR1AHTR2AHTR2CSLC6A4HTR5A | |
| SCHEMBL6965752 | 0.75 | HTR1A (0.59) | HTR1AHTR2AHTR2CSLC6A4HTR5A | |
| SCHEMBL6965294 | 0.75 | HTR1D (0.56) | HTR1AHTR2AHTR2CSLC6A4HTR5A | |
| Hydrochloric Acid SCHEMBL6979124 | 0.74 | HTR1D (0.55) | HTR1AHTR2AHTR2CSLC6A4HTR5A | |
| SCHEMBL6969558 | 0.74 | MPO (0.60) | HTR2AHTR1DHTR1BMPOHTR7 | |
| Bufotenine SCHEMBL518028 | 0.72 | HTR2C (1.00) | HTR1AHTR2AHTR2CSLC6A4HTR5A | |
| Bufotenine SCHEMBL29353068 | 0.72 | HTR2C (1.00) | HTR1AHTR2AHTR2CSLC6A4HTR5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944595-B1 | 5-CYCLO INDOLE COMPOUNDS AS 5-HT1D RECEPTOR LIGANDS | NPS ALLELIX CORP (CA) | 2003-10-01 | — | — | EP | claimed |
| US-5998438-A | SEROTONIN RECEPTOR ANTAGONIST; HEADACHE THERAPY | ALLELIX BIOPHARMACEUTICALS, INC. (CA) | 1999-12-07 | — | — | US | claimed |
| EP-0944595-B1 | 5-CYCLO INDOLE COMPOUNDS AS 5-HT1D RECEPTOR LIGANDS | NPS ALLELIX CORP (CA) | 2003-10-01 | — | — | EP | disclosed |
| US-5998438-A | SEROTONIN RECEPTOR ANTAGONIST; HEADACHE THERAPY | ALLELIX BIOPHARMACEUTICALS, INC. (CA) | 1999-12-07 | — | — | US | disclosed |