Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 3/20 | 0.60 |
| ▸ | HTR2A | P28223 | 3/20 | 0.59 |
| ▸ | HTR1D | P28221 | 10/20 | 0.58 |
| ▸ | HTR1B | P28222 | 10/20 | 0.58 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6967767 | 0.91 | HTR1D (0.59) | MPOHTR2AHTR1DHTR1BDRD3 | |
| SCHEMBL6966135 | 0.90 | MPO (0.57) | MPOHTR2AHTR1DHTR1BDRD3 | |
| SCHEMBL6967771 | 0.88 | MPO (0.55) | MPOHTR2AHTR1DHTR1BDRD3 | |
| SCHEMBL6968414 | 0.85 | DRD3 (0.56) | MPOHTR2AHTR1DHTR1BDRD3 | |
| SCHEMBL6970858 | 0.81 | MPO (0.58) | MPOHTR2AHTR1DHTR1BBRD4 | |
| SCHEMBL6968234 | 0.81 | HTR1D (0.53) | MPOHTR2AHTR1DHTR1BDRD3 | |
| SCHEMBL26989598 | 0.80 | HTR7 (0.70) | MPOHTR2AHTR1DHTR1BDRD3 | |
| SCHEMBL6968418 | 0.79 | MPO (0.45) | MPOHTR2AHTR1DHTR1BBRD4 | |
| SCHEMBL27095364 | 0.78 | HTR7 (0.71) | MPOHTR2AHTR1DHTR1BDRD3 | |
| SCHEMBL6969556 | 0.77 | SLC6A4 (0.61) | HTR2AHTR1DDRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944595-B1 | 5-CYCLO INDOLE COMPOUNDS AS 5-HT1D RECEPTOR LIGANDS | NPS ALLELIX CORP (CA) | 2003-10-01 | — | — | EP | claimed |
| EP-0944595-B1 | 5-CYCLO INDOLE COMPOUNDS AS 5-HT1D RECEPTOR LIGANDS | NPS ALLELIX CORP (CA) | 2003-10-01 | — | — | EP | disclosed |
| US-5998438-A | SEROTONIN RECEPTOR ANTAGONIST; HEADACHE THERAPY | ALLELIX BIOPHARMACEUTICALS, INC. (CA) | 1999-12-07 | — | — | US | disclosed |