Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | FDPS | P14324 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6972809 | 0.83 | KMT2A (0.56) | KMT2AKDM4EALDH1A1HSD17B10GAA | |
| SCHEMBL6967373 | 0.79 | TDP1 (0.51) | KMT2AAKR1B1CA12CA9KDM4E | |
| SCHEMBL6968780 | 0.73 | KMT2A (0.55) | KMT2AAKR1B1ALDH1A1CYP1A2MAPT | |
| SCHEMBL8143584 | 0.73 | KMT2A (0.76) | KMT2ACA12CA9ALDH1A1MAPT | |
| SCHEMBL3586863 | 0.73 | KDM4E (0.67) | KMT2AAKR1B1KDM4EALDH1A1HPGD | |
| SCHEMBL2125547 | 0.70 | ALDH1A1 (0.50) | AKR1B1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL8144325 | 0.69 | KMT2A (0.56) | KMT2AAKR1B1ALDH1A1MAPT | |
| SCHEMBL8143249 | 0.67 | CYP1A2 (0.61) | KMT2ACA12CA9MEN1CYP1A2 | |
| SCHEMBL7549529 | 0.67 | CA12 (0.60) | KMT2AAKR1B1CA12CA9KDM4E | |
| SCHEMBL8143252 | 0.67 | KMT2A (0.53) | KMT2ACA12CA9KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0718289-B1 | Novel parabanic acid derivatives as aldose reductase inhibitors | NIPPON ZOKI PHARMACEUTICAL CO (JP) | 2003-03-05 | — | — | EP | disclosed |
| EP-0718289-A1 | Novel parabanic acid derivatives as aldose reductase inhibitors | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 1996-06-26 | — | — | EP | disclosed |