Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 6/20 | 0.41 |
| ▸ | FAAH | O00519 | 5/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8328132 | 0.90 | MGLL (0.41) | CYP1A2CYP2D6MGLLFAAH | |
| SCHEMBL5661991 | 0.82 | MGLL (0.42) | CYP1A2CYP2D6MGLLFAAH | |
| SCHEMBL5661272 | 0.82 | MGLL (0.42) | CYP1A2CYP2D6MGLLFAAH | |
| SCHEMBL5663686 | 0.82 | MGLL (0.42) | CYP1A2CYP2D6MGLLFAAH | |
| SCHEMBL7232423 | 0.81 | MGLL (0.39) | CYP1A2CYP2D6MGLLFAAH | |
| SCHEMBL7564445 | 0.80 | MGLL (0.39) | CYP1A2CYP2D6MGLLFAAH | |
| SCHEMBL7962604 | 0.80 | CYP1A2 (0.41) | CYP1A2CYP2D6MGLLFAAH | |
| SCHEMBL7674563 | 0.78 | CRHBP (0.47) | CYP1A2CYP2D6MGLL | |
| SCHEMBL7674567 | 0.78 | CRHBP (0.47) | CYP1A2CYP2D6MGLL | |
| SCHEMBL6956458 | 0.77 | MGLL (0.40) | CYP1A2CYP2D6MGLLFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6620815-B1 | Selective antagonists for human alpha 1A receptors; benign prostatic hyperplasia, impotency, cardiac arrhythmia treatment; anticholesterol agents; intraocular pressure reduction | SYNAPTIC PHARMACEUTICAL CORPORATION | 2003-09-16 | — | — | US | disclosed |
| EP-0988295-A4 | HETEROCYCLIC SUBSTITUTED PIPERIDINES AND USES THEREOF | SYNAPTIC PHARMA CORP (US) | 2003-08-13 | — | — | EP | disclosed |
| US-6159990-A | Oxazolidinones as α1A receptor antagonists | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-12-12 | — | — | US | disclosed |
| EP-0988295-A1 | HETEROCYCLIC SUBSTITUTED PIPERIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-03-29 | — | — | EP | disclosed |
| WO-1998057940-A1 | HETEROCYCLIC SUBSTITUTED PIPERIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1998-12-23 | — | — | WO | disclosed |