Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 5/20 | 0.70 |
| ▸ | CA12 | O43570 | 4/20 | 0.70 |
| ▸ | CA1 | P00915 | 4/20 | 0.70 |
| ▸ | CA9 | Q16790 | 4/20 | 0.70 |
| ▸ | FPR2 | P25090 | 1/20 | 0.68 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.65 |
| ▸ | CNR1 | P21554 | 4/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | CA4 | P22748 | 1/20 | 0.58 |
| ▸ | CA5A | P35218 | 1/20 | 0.58 |
| ▸ | CA7 | P43166 | 1/20 | 0.58 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4657957 | 0.94 | CA2 (0.64) | CA2CA12CA1CA9FPR2 | |
| SCHEMBL16857481 | 0.94 | CNR1 (0.73) | CA2CA12CA1CA9FPR2 | |
| SCHEMBL4606056 | 0.89 | EPHX1 (0.81) | CA2CA12CA1CA9FPR2 | |
| SCHEMBL5376426 | 0.86 | CNR1 (0.63) | CA2CA12CA1CA9FPR2 | |
| SCHEMBL19472678 | 0.86 | FPR2 (0.69) | CA2CA12CA1CA9FPR2 | |
| SCHEMBL14466285 | 0.84 | KMT2A (0.71) | CA2CA12CA1CA9FPR2 | |
| SCHEMBL15940162 | 0.83 | ESRRG (0.57) | CA2CA12CA1CA9EPHX1 | |
| SCHEMBL11615935 | 0.81 | ROCK2 (0.79) | CA2CA12CA1CA9FPR2 | |
| SCHEMBL17117221 | 0.81 | EPHX2 (0.67) | CA2CA12CA1CA9EPHX1 | |
| SCHEMBL6344432 | 0.81 | RAB9A (0.55) | CA2CA12CA1CA9EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0713483-B1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | ASTRAZENECA AB (SE) | 2003-01-15 | — | — | EP | disclosed |
| US-6030985-A | Amidine derivatives with nitric oxide synthetase activities | ASTRA AKTIEBOLAG (SE) | 2000-02-29 | — | — | US | disclosed |
| US-5807885-A | Amidine derivatives with nitric oxide synthetase activities | ASTRA AKTIEBOLAG (SE) | 1998-09-15 | — | — | US | disclosed |
| EP-0713483-A1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | Astra Aktiebolag (SE) | 1996-05-29 | — | — | EP | disclosed |
| WO-1995005363-A1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | ASTRA AKTIEBOLAG (SE) | 1995-02-23 | — | — | WO | disclosed |