Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 3/20 | 0.46 |
| ▸ | NOS1 | P29475 | 2/20 | 0.46 |
| ▸ | NOS2 | P35228 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.43 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | CASP2 | P42575 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6964306 | 0.90 | NOS3 (0.43) | NOS3NOS1NOS2NPC1RAB9A | |
| SCHEMBL6962276 | 0.87 | NPC1 (0.52) | NOS3NOS1NOS2NPC1RAB9A | |
| SCHEMBL6962883 | 0.86 | NOS3 (0.49) | NOS3NOS1NOS2NPC1RAB9A | |
| SCHEMBL29558856 | 0.85 | NOS3 (0.64) | NOS3NOS1NOS2NPC1RAB9A | |
| SCHEMBL122445 | 0.85 | NOS3 (0.64) | NOS3NOS1NOS2NPC1RAB9A | |
| SCHEMBL27357975 | 0.85 | NOS3 (0.47) | NOS3NOS1NOS2NPC1RAB9A | |
| Hydrochloric Acid SCHEMBL31114391 | 0.84 | NOS3 (0.65) | NOS3NOS1NOS2NPC1RAB9A | |
| SCHEMBL6958210 | 0.84 | GAA (0.49) | NOS3NOS1NOS2NPC1RAB9A | |
| SCHEMBL6962454 | 0.84 | L3MBTL1 (0.51) | NOS3NOS1NOS2NPC1RAB9A | |
| SCHEMBL6963560 | 0.84 | GAA (0.49) | NOS3NOS1NOS2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0713483-B1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | ASTRAZENECA AB (SE) | 2003-01-15 | — | — | EP | disclosed |
| US-6030985-A | Amidine derivatives with nitric oxide synthetase activities | ASTRA AKTIEBOLAG (SE) | 2000-02-29 | — | — | US | disclosed |
| US-5807885-A | Amidine derivatives with nitric oxide synthetase activities | ASTRA AKTIEBOLAG (SE) | 1998-09-15 | — | — | US | disclosed |