Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.41 |
| ▸ | APP | P05067 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.38 |
| ▸ | CCR3 | P51677 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.34 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6978231 | 0.92 | L3MBTL1 (0.40) | APPSIGMAR1ALDH1A1CYP3A4CYP2D6 | |
| SCHEMBL6966441 | 0.86 | OPRL1 (0.38) | CCR3ADRA1AADRA2AADRA2BADRA2C | |
| SCHEMBL6967295 | 0.85 | CCR3 (0.42) | SIGMAR1CCR3ALDH1A1KDM4EC5AR1 | |
| SCHEMBL6966767 | 0.84 | LSS (0.37) | SIGMAR1CCR3CYP3A4CYP2D6SMN1; SMN2 | |
| SCHEMBL6968412 | 0.84 | OPRL1 (0.39) | SIGMAR1CCR3NPSR1SMN1; SMN2 | |
| SCHEMBL6975759 | 0.84 | KDM4E (0.38) | CCR3ALDH1A1CYP2D6KDM4EGAA | |
| SCHEMBL6976709 | 0.82 | CCR3 (0.45) | SIGMAR1CCR3CYP3A4CYP2D6KDM4E | |
| SCHEMBL6969244 | 0.81 | CHKA (0.45) | SIGMAR1ALDH1A1KDM4E | |
| SCHEMBL6977411 | 0.81 | CCR3 (0.41) | SIGMAR1CCR3ALDH1A1KDM4E | |
| SCHEMBL6973584 | 0.80 | SIGMAR1 (0.40) | SIGMAR1CCR3ALDH1A1KDM4EC5AR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | claimed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | claimed |
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | disclosed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | disclosed |