SCHEMBL6967935

SCHEMBL6967935

N=CN.c1ccc(CCc2c[nH]cn2)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNH2 Q12809 1/20 0.42
NOS1 P29475 1/20 0.38
BACE1 P56817 2/20 0.38
TAAR1 Q96RJ0 2/20 0.37
MAOA P21397 3/20 0.36
MAOB P27338 3/20 0.36
CYP2A6 P11509 1/20 0.34
HTR2A P28223 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
LOXL2 Q9Y4K0 1/20 0.34
DAO P14920 1/20 0.34
PDE10A Q9Y233 1/20 0.34
DHFR P00374 1/20 0.34
TLR8 Q9NR97 1/20 0.34
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
IP6K1 Q92551 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1753940 0.90 KCNH2 (0.50) KCNH2NOS1BACE1TAAR1MAOA
SCHEMBL6967970 0.85 ALDH1A1 (0.39) TAAR1MAOBSMN1; SMN2TLR8
SCHEMBL10743482 0.80 HTR2A (0.42) KCNH2NOS1MAOAMAOBHTR2A
SCHEMBL7620595 0.79 GPR52 (0.40) KCNH2TAAR1
SCHEMBL4394413 0.79 GPR52 (0.40) KCNH2TAAR1
SCHEMBL4384692 0.79 GPR52 (0.40) KCNH2TAAR1
SCHEMBL4390050 0.78 HRH3 (0.45) MAOAMAOBDHFR
SCHEMBL3151668 0.76 GFER (0.52) MAOAMAOBSMN1; SMN2LOXL2CYP3A4
SCHEMBL6180571 0.75 SIGMAR1 (0.50) KCNH2
SCHEMBL5827293 0.74 MAOB (0.53) NOS1BACE1MAOAMAOBSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0729459-B1 PHENYL-ALKYL IMIDAZOLES AS H3-RECEPTOR ANTAGONISTS SCHERING CORP (US) 2003-03-12 EP disclosed
US-5578616-A ANTIINFLAMMATORY AGENTS, ANTIALLERGENS, TREATMENT FOR GASTROINTESTINAL AND CARDIOVASCULAR DISORDERS SCHERING CORPORATION (US) 1996-11-26 US disclosed