Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6968615 | 1.00 | KDM4E (0.34) | KDM4ESMN1; SMN2TDP1L3MBTL1MAPT | |
| SCHEMBL2812354 | 0.74 | SMN1; SMN2 (0.54) | KDM4ESMN1; SMN2TDP1L3MBTL1MAPT | |
| SCHEMBL2997336 | 0.74 | SMN1; SMN2 (0.54) | KDM4ESMN1; SMN2TDP1L3MBTL1MAPT | |
| SCHEMBL2812357 | 0.74 | SMN1; SMN2 (0.54) | KDM4ESMN1; SMN2TDP1L3MBTL1MAPT | |
| SCHEMBL51251 | 0.73 | TSHR (0.48) | KDM4ETDP1L3MBTL1MAPTTSHR | |
| SCHEMBL6965172 | 0.71 | KDM4E (0.39) | KDM4ESMN1; SMN2TDP1L3MBTL1MAPT | |
| SCHEMBL6965168 | 0.71 | KDM4E (0.39) | KDM4ESMN1; SMN2TDP1L3MBTL1MAPT | |
| SCHEMBL6972237 | 0.71 | HIF1A (0.41) | MAPTTSHR | |
| SCHEMBL6972239 | 0.71 | HIF1A (0.41) | MAPTTSHR | |
| SCHEMBL1426474 | 0.70 | NPC1 (0.43) | SMN1; SMN2L3MBTL1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | disclosed |