Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 7/20 | 0.33 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.33 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.33 |
| ▸ | GCGR | P47871 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.32 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6969846 | 0.94 | KDM4E (0.33) | ALDH1A1SMN1; SMN2KDM4ELMNAHPGD | |
| SCHEMBL6960543 | 0.90 | GCGR (0.33) | ALDH1A1SMN1; SMN2KDM4ELMNAHPGD | |
| SCHEMBL6965833 | 0.89 | ALDH1A1 (0.32) | ALDH1A1SMN1; SMN2KDM4ELMNAHPGD | |
| SCHEMBL6957642 | 0.87 | ALDH1A1 (0.34) | ALDH1A1SMN1; SMN2KDM4ELMNAHPGD | |
| SCHEMBL6974486 | 0.85 | TLR8 (0.35) | ALDH1A1TLR8HSP90B1TRAP1HSP90AA1 | |
| SCHEMBL7081079 | 0.85 | HSP90B1 (0.33) | ALDH1A1SMN1; SMN2KDM4ELMNAHPGD | |
| SCHEMBL6964951 | 0.85 | ALDH1A1 (0.32) | ALDH1A1SMN1; SMN2KDM4ELMNAHPGD | |
| SCHEMBL7078876 | 0.84 | TLR7 (0.38) | ALDH1A1KDM4ELMNAHPGDTLR8 | |
| SCHEMBL6970195 | 0.83 | TLR7 (0.35) | ALDH1A1KDM4ENPSR1TLR8HSP90B1 | |
| SCHEMBL6965285 | 0.83 | GCGR (0.30) | GCGR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |