Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6957642 | 0.95 | ALDH1A1 (0.34) | ALDH1A1KDM4ELMNAHPGDSMN1; SMN2 | |
| SCHEMBL7083579 | 0.91 | ALDH1A1 (0.32) | ALDH1A1POLBMAPK1P2RX3 | |
| SCHEMBL6960825 | 0.90 | ALDH1A1 (0.32) | ALDH1A1POLBMAPK1 | |
| SCHEMBL6960943 | 0.88 | AGTR1 (0.35) | ALDH1A1KDM4ELMNA | |
| SCHEMBL7081352 | 0.87 | TDP1 (0.31) | SMN1; SMN2 | |
| SCHEMBL6966285 | 0.87 | P2RX3 (0.33) | ALDH1A1KDM4EHPGDSMN1; SMN2P2RX3 | |
| SCHEMBL6969846 | 0.86 | KDM4E (0.33) | ALDH1A1KDM4ELMNAHPGDSMN1; SMN2 | |
| SCHEMBL7084635 | 0.85 | ADRA1D (0.35) | ALDH1A1KDM4EHPGDSMN1; SMN2MAPK1 | |
| SCHEMBL6973223 | 0.85 | TDP1 (0.33) | ALDH1A1KDM4ELMNAHPGDSMN1; SMN2 | |
| SCHEMBL6973396 | 0.85 | PIM1 (0.34) | P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |