Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 2/20 | 0.35 |
| ▸ | HTR7 | P34969 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.35 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6970497 | 0.87 | LMNA (0.47) | JAK2JAK1OPRL1ALDH1A1TDP1 | |
| Hydrochloric Acid SCHEMBL6981064 | 0.86 | POLB (0.46) | JAK2JAK1OPRL1ALDH1A1TDP1 | |
| SCHEMBL6976284 | 0.86 | OPRL1 (0.48) | OPRL1ALDH1A1KMT2AOPRD1OPRK1 | |
| SCHEMBL6973419 | 0.84 | OPRL1 (0.53) | FAAHOPRL1TDP1KMT2APOLB | |
| SCHEMBL6972025 | 0.84 | ALDH1A1 (0.42) | OPRL1ALDH1A1DRD4HTT | |
| SCHEMBL6976116 | 0.84 | CCR3 (0.46) | OPRL1ALDH1A1DRD4KMT2AOPRM1 | |
| Hydrochloric Acid SCHEMBL6976215 | 0.83 | ALDH1A1 (0.41) | OPRL1ALDH1A1DRD4POLBHTT | |
| Hydrochloric Acid SCHEMBL6976568 | 0.83 | OPRL1 (0.52) | FAAHOPRL1TDP1KMT2APOLB | |
| SCHEMBL6975032 | 0.83 | OPRD1 (0.42) | OPRL1ALDH1A1KMT2AOPRD1OPRK1 | |
| Hydrochloric Acid SCHEMBL6971416 | 0.83 | CCR3 (0.45) | OPRL1ALDH1A1DRD4KMT2AOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | claimed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | claimed |
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | disclosed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | disclosed |