Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 2/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | DOCK5 | Q9H7D0 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPFFR1 | Q9GZQ6 | 1/20 | 0.38 |
| ▸ | NPFFR2 | Q9Y5X5 | 1/20 | 0.38 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6976568 | 0.99 | OPRL1 (0.52) | OPRL1SIGMAR1CXCR3POLBSMN1; SMN2 | |
| SCHEMBL6976116 | 0.89 | CCR3 (0.46) | OPRL1SIGMAR1CXCR3POLBSMN1; SMN2 | |
| SCHEMBL6976284 | 0.88 | OPRL1 (0.48) | OPRL1SIGMAR1POLBMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL6971416 | 0.87 | CCR3 (0.45) | OPRL1SIGMAR1CXCR3POLBSMN1; SMN2 | |
| SCHEMBL6969059 | 0.87 | SIGMAR1 (0.51) | OPRL1SIGMAR1POLBKDM4EL3MBTL1 | |
| SCHEMBL6970497 | 0.85 | LMNA (0.47) | OPRL1SIGMAR1CXCR3POLBSMN1; SMN2 | |
| SCHEMBL6975032 | 0.85 | OPRD1 (0.42) | OPRL1SIGMAR1CXCR3POLBKDM4E | |
| SCHEMBL6972025 | 0.84 | ALDH1A1 (0.42) | OPRL1SIGMAR1HTT | |
| SCHEMBL6968917 | 0.84 | JAK2 (0.41) | OPRL1POLBKDM4ETDP1FAAH | |
| Hydrochloric Acid SCHEMBL6980309 | 0.84 | OPRD1 (0.41) | OPRL1SIGMAR1CXCR3POLBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | claimed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | claimed |
| US-6566376-B1 | For therapy of chemokine receptor related diseases and conditions such as rheumatoid arthritis, chronic obstructive pulmonary disease | ASTRAZENECA UK LIMITED (GB) | 2003-05-20 | — | — | US | disclosed |
| EP-1202984-B1 | DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LTD (GB) | 2003-03-05 | — | — | EP | disclosed |
| EP-1202984-A1 | NOVEL DIPHENYL-PIPERIDINE DERIVATE | AstraZeneca UK Limited (GB) | 2002-05-08 | — | — | EP | disclosed |
| WO-2001005782-A1 | NOVEL DIPHENYL-PIPERIDINE DERIVATE | ASTRAZENECA UK LIMITED (GB) | 2001-01-25 | — | — | WO | disclosed |