Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | P2RX3 | P56373 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | TOP2A | P11388 | 1/20 | 0.31 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.31 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.30 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.30 |
| ▸ | ITGAL | P20701 | 1/20 | 0.30 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6961267 | 0.90 | ALDH1A1 (0.34) | MAPTTP53P2RX3ALDH1A1 | |
| SCHEMBL6976430 | 0.90 | HTT (0.34) | ALDH1A1TLR7 | |
| SCHEMBL6967842 | 0.89 | ENPP2 (0.33) | TP53P2RX3ENPP2 | |
| SCHEMBL6961663 | 0.89 | P2RX3 (0.31) | P2RX3 | |
| SCHEMBL6974505 | 0.89 | TOP2A (0.42) | P2RX3ALDH1A1TOP2ATOP2BENPP2 | |
| SCHEMBL7083670 | 0.88 | ENPP2 (0.33) | P2RX3ENPP2 | |
| SCHEMBL6963992 | 0.86 | MAPT (0.37) | MAPTALDH1A1POLB | |
| SCHEMBL6975076 | 0.86 | TOP2A (0.31) | ALDH1A1TOP2ATOP2B | |
| SCHEMBL7182670 | 0.86 | TLR7 (0.31) | TP53ALDH1A1POLBKDM4ETLR7 | |
| SCHEMBL6975053 | 0.85 | MEN1 (0.41) | MAPTTP53P2RX3ALDH1A1ENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |