Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7085898 | 0.90 | ALDH1A1 (0.37) | HTTSMN1; SMN2S1PR3ALDH1A1GAA | |
| SCHEMBL7083490 | 0.90 | GRIN1 (0.35) | HTTSMN1; SMN2S1PR3TLR7CYP3A4 | |
| SCHEMBL6968937 | 0.90 | MAPT (0.32) | TLR7ALDH1A1 | |
| SCHEMBL6974277 | 0.90 | GRIN1 (0.34) | HTTSMN1; SMN2S1PR3TLR7ALDH1A1 | |
| SCHEMBL7080182 | 0.90 | MAPT (0.35) | HTTSMN1; SMN2S1PR3HIF1AALDH1A1 | |
| SCHEMBL6964229 | 0.89 | TOP2A (0.41) | S1PR3CYP3A4 | |
| SCHEMBL6962639 | 0.87 | RXFP1 (0.37) | HTTSMN1; SMN2ALDH1A1GAA | |
| SCHEMBL6969306 | 0.86 | KMT2A (0.39) | HTTSMN1; SMN2S1PR3CYP3A4HIF1A | |
| SCHEMBL7086385 | 0.85 | TLR7 (0.35) | HTTS1PR3TLR7CYP3A4HIF1A | |
| SCHEMBL6975076 | 0.84 | TOP2A (0.31) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0786455-B1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO (JP) | 2003-12-03 | — | — | EP | disclosed |
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |