Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | HASPIN | Q8TF76 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6963410 | 0.96 | KDM4E (0.36) | KDM4ERAD52KMT2ATDP1MEN1 | |
| SCHEMBL6974563 | 0.81 | KDM4E (0.41) | KDM4ERAD52KMT2ATDP1MAPT | |
| SCHEMBL6971485 | 0.80 | LMNA (0.40) | KMT2AMEN1GAAL3MBTL1MAPK1 | |
| SCHEMBL6973974 | 0.79 | LMNA (0.40) | KMT2AMEN1GAAL3MBTL1MAPK1 | |
| SCHEMBL6970234 | 0.78 | MAPT (0.46) | KDM4EKMT2ATDP1MEN1MAPT | |
| SCHEMBL6974578 | 0.77 | HTT (0.41) | KMT2ATDP1MEN1MAPTNPSR1 | |
| SCHEMBL8357964 | 0.76 | SLC6A2 (0.49) | KDM4EKMT2ATDP1MEN1MAPT | |
| SCHEMBL6971375 | 0.76 | MAPT (0.44) | KDM4EKMT2ATDP1MEN1MAPT | |
| SCHEMBL6963335 | 0.75 | LMNA (0.46) | KMT2ATDP1MEN1MAPTNPSR1 | |
| SCHEMBL6972315 | 0.75 | LMNA (0.46) | KMT2ATDP1MEN1MAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0855391-B1 | NOVEL ISOQUINOLINE DERIVATIVES | DAIICHI SEIYAKU CO (JP) | 2003-10-15 | — | — | EP | disclosed |
| US-5959107-A | Isoquinoline derivatives | SNOW BRAND MILK PRODUCTS CO., LTD. (JP) | 1999-09-28 | — | — | US | disclosed |
| EP-0855391-A1 | NOVEL ISOQUINOLINE DERIVATIVES | SNOW BRAND MILK PRODUCTS CO., LTD. (JP) | 1998-07-29 | — | — | EP | disclosed |