Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TYMS | P04818 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 1/20 | 0.38 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6970234 | 0.81 | MAPT (0.46) | MAPTGAARAB9AALDH1A1KDM4E | |
| SCHEMBL6961855 | 0.80 | MEN1 (0.41) | MAPTGAARAB9AALDH1A1HPGD | |
| SCHEMBL6967350 | 0.79 | SMN1; SMN2 (0.44) | MAPTGAARAB9AALDH1A1KDM4E | |
| SCHEMBL6974578 | 0.79 | HTT (0.41) | MAPTGAARAB9AALDH1A1NPC1 | |
| SCHEMBL8357964 | 0.79 | SLC6A2 (0.49) | MAPTGAARAB9AALDH1A1KDM4E | |
| SCHEMBL6963335 | 0.77 | LMNA (0.46) | MAPTGAARAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL6972315 | 0.77 | LMNA (0.46) | MAPTGAARAB9AALDH1A1SMN1; SMN2 | |
| SCHEMBL6970313 | 0.76 | PGR (0.39) | MAPTGAARAB9AALDH1A1NPC1 | |
| SCHEMBL6974324 | 0.76 | KMT2A (0.40) | MAPTGAARAB9AALDH1A1HPGD | |
| SCHEMBL6959978 | 0.76 | KMT2A (0.40) | MAPTGAARAB9AALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0855391-B1 | NOVEL ISOQUINOLINE DERIVATIVES | DAIICHI SEIYAKU CO (JP) | 2003-10-15 | — | — | EP | disclosed |
| US-5959107-A | Isoquinoline derivatives | SNOW BRAND MILK PRODUCTS CO., LTD. (JP) | 1999-09-28 | — | — | US | disclosed |
| EP-0855391-A1 | NOVEL ISOQUINOLINE DERIVATIVES | SNOW BRAND MILK PRODUCTS CO., LTD. (JP) | 1998-07-29 | — | — | EP | disclosed |