Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.41 |
| ▸ | RAD52 | P43351 | 1/20 | 0.39 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | RHEB | Q15382 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6963410 | 0.83 | KDM4E (0.36) | KDM4ERAD52KMT2ATSHRMAPT | |
| SCHEMBL6969044 | 0.81 | KDM4E (0.36) | KDM4ERAD52KMT2ATSHRMAPT | |
| SCHEMBL6962804 | 0.76 | TNF (0.47) | DCTPP1CYP11B2RAB9A | |
| SCHEMBL1048487 | 0.72 | KDM4E (0.58) | KDM4ERAD52DCTPP1KMT2ATSHR | |
| SCHEMBL6962927 | 0.72 | LMNA (0.51) | KDM4ERAD52MAPTLMNASMN1; SMN2 | |
| SCHEMBL6968741 | 0.71 | KDM4E (0.57) | KDM4EKMT2AMAPTLMNASMN1; SMN2 | |
| SCHEMBL6963124 | 0.70 | LMNA (0.41) | KDM4EMAPTLMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL6973974 | 0.67 | LMNA (0.40) | KMT2ATSHRLMNASMN1; SMN2RAB9A | |
| SCHEMBL6971485 | 0.67 | LMNA (0.40) | KMT2ATSHRLMNASMN1; SMN2RAB9A | |
| SCHEMBL6963171 | 0.66 | AR (0.53) | KDM4ELMNACYP11B1CYP11B2RHEB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0855391-B1 | NOVEL ISOQUINOLINE DERIVATIVES | DAIICHI SEIYAKU CO (JP) | 2003-10-15 | — | — | EP | disclosed |
| US-5959107-A | Isoquinoline derivatives | SNOW BRAND MILK PRODUCTS CO., LTD. (JP) | 1999-09-28 | — | — | US | disclosed |
| EP-0855391-A1 | NOVEL ISOQUINOLINE DERIVATIVES | SNOW BRAND MILK PRODUCTS CO., LTD. (JP) | 1998-07-29 | — | — | EP | disclosed |