SCHEMBL696908

SCHEMBL696908

O=C(Cl)Oc1ccc(F)cc1

nearest known ligand 0.44

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 3/20 0.44
ATM Q13315 1/20 0.44
CES2 O00748 1/20 0.42
CES1 P23141 1/20 0.42
SMN1; SMN2 Q16637 2/20 0.40
KDM4E B2RXH2 2/20 0.40
ALDH1A1 P00352 2/20 0.40
FAAH O00519 2/20 0.40
S1PR2 O95136 1/20 0.40
CYP1A2 P05177 1/20 0.40
HPGD P15428 1/20 0.40
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
NR4A2 P43354 1/20 0.39
MEN1 O00255 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8103460 0.90 MAPT (0.46) KMT2AATMSMN1; SMN2CYP1A2MEN1
SCHEMBL6924446 0.87 RAB9A (0.46) KMT2ASMN1; SMN2ALDH1A1MEN1
SCHEMBL6565732 0.80 HSD17B10 (0.47) KMT2ASMN1; SMN2KDM4EALDH1A1CYP1A2
SCHEMBL6564201 0.80 ELANE (0.52) KMT2ASMN1; SMN2ALDH1A1HPGDMEN1
SCHEMBL57245 0.80 KMT2A (0.50) KMT2AATMCES2CES1SMN1; SMN2
SCHEMBL18697279 0.78 KMT2A (0.46) KMT2AATMCES2CES1SMN1; SMN2
SCHEMBL17434705 0.78 KMT2A (0.46) KMT2AATMCES2CES1SMN1; SMN2
SCHEMBL9578961 0.78 MAPT (0.50) KMT2AKDM4EALDH1A1HPGDCA1
SCHEMBL59462 0.78 ELANE (0.48) KMT2ACES2CES1SMN1; SMN2CYP1A2
SCHEMBL14389790 0.78 KMT2A (0.46) KMT2AATMCES2CES1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 678 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210130395-A1 PROXIMITY INDUCED SITE-SPECIFIC ANTIBODY CONJUGATION WILLIAM MARSH RICE UNIVERSITY (US) 2021-05-06 US claimed
WO-2019217900-A1 PROXIMITY INDUCED SITE-SPECIFIC ANTIBODY CONJUGATION WILLIAM MARSH RICE UNIVERSITY (US) 2019-11-14 WO claimed
EP-1506176-B1 AMINOINDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM PFIZER ITALIA SRL (IT) 2013-04-24 EP claimed
EP-1315729-B1 COMPOUNDS IN THE FORM OF HOMODIMERIC OR HETERODIMERIC PRODRUGS; PROCESS FOR OBTAINING THESE PRODRUGS AND THEIR ACCEPTABLE PHARMACEUTICAL SALTS AND USE OF COMPOUNDS IN THE TREATMENT OF PHOSPHODIESTERASES-MEDIATED DISEASES OR DYSFUNCTION CRISTALIA PROD QUIMICOS FARM (BR) 2008-01-09 EP claimed
EP-1315729-A4 COMPOUNDS IN THE FORM OF HOMODIMERIC, HETERODIMERIC AND/OR HOMO AND HETEROMULTIMERIC PRO-DRUGS; PROCESS FOR OBTAINING THESE PRO-DRUGS AND THEIR ACCEPTABLE PHARMACEUTICAL SALTS AND USE OF COMPOUNDS IN THE TREATMENT OF PHOSPHODIESTERASIS-MEDIATED DISEASES OR DYSFUNCTION CRISTALIA PRODUTOS QUIMICOS E (BR) 2004-07-07 EP claimed
US-20040106629-A1 Compouds in the form of homodimeric, heterodimeric and/or homo and heteromultimeric pro-drugs; process for obtaining these pro-drugs and their acceptable pharmaceutical salts and use of compounds in the treatment of phosphodiesterasis-mediated deseases or dysfunction PACHECO, OGARI (BR) 2004-06-03 US claimed
EP-1315729-A1 COMPOUNDS IN THE FORM OF HOMODIMERIC, HETERODIMERIC AND/OR HOMO AND HETEROMULTIMERIC PRO-DRUGS; PROCESS FOR OBTAINING THESE PRO-DRUGS AND THEIR ACCEPTABLE PHARMACEUTICAL SALTS AND USE OF COMPOUNDS IN THE TREATMENT OF PHOSPHODIESTERASIS-MEDIATED DISEASES OR DYSFUNCTION Cristalia Produtos Quimicos e Farmaceuticos Ltda (BR) 2003-06-04 EP claimed
WO-2002012241-A1 COMPOUNDS IN THE FORM OF HOMODIMERIC, HETERODIMERIC AND/OR HOMO AND HETEROMULTIMERIC PRO-DRUGS; PROCESS FOR OBTAINING THESE PRO-DRUGS AND THEIR ACCEPTABLE PHARMACEUTICAL SALTS AND USE OF COMPOUNDS IN THE TREATMENT OF PHOSPHODIESTERASIS-MEDIATED DISEASES OR DYSFUNCTION Cristália Produtos Químicos e Farmacêuticos Ltda. (BR) 2002-02-14 WO claimed
US-20260070884-A1 Inhibitors of Dihydroceramide Desaturase for Treating Disease CENTAURUS THERAPEUTICS (US) 2026-03-12 US disclosed
EP-4680607-A1 BICYCLIC UREAS AS KINASE INHIBITORS Incyte Corporation (US) 2026-01-21 EP disclosed
EP-4673179-A1 BONE-DIRECTED THERAPEUTICS FOR THE TREATMENT OF CANCER William Marsh Rice University (US) 2026-01-07 EP disclosed
US-20250388592-A1 (AZA)SPIROHEPTANE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS REMYND N.V. (BE) 2025-12-25 US disclosed
EP-4654968-A1 PROCESS FOR THE PREPARATION OF TIVOZANIB OR A SALT THEREOF Alivus Life Sciences Limited (IN) 2025-12-03 EP disclosed
EP-4651872-A1 COMPOUNDS, COMPOSITIONS AND METHODS OF USE TO TREAT HYPOPARATHYROIDISM AND OSTEOPOROSIS Septerna, Inc. (US) 2025-11-26 EP disclosed
US-5231107-A Compounds for treatment of Alzheimer*s disease or memory defects ROUSSEL UCLAF (FR) 1993-07-27 US disclosed
EP-0509769-A2 Heterocyclic amides having HLE inhibiting activity ZENECA LIMITED (GB) 1992-10-21 EP disclosed
US-5140041-A Cognition activators, for treatment of Alzheimer's disease NISSHIN FLOUR MILLING CO., LTD. (JP) 1992-08-18 US disclosed
EP-0443474-A2 1-Phenoxycarbonyl-2-pyrrolidinone derivatives and nootropic agents NISSHIN FLOUR MILLING CO., LTD. (JP) 1991-08-28 EP disclosed
US-4003909-A [(1,2,4-Oxadiazol-3-yl)phenyl]carbamic or thiocarbamic acid esters E. R. SQUIBB & SONS, INC. (US) 1977-01-18 US disclosed
US-3986973-A CYANOFORMATES AND CYANOFORMAMIDES AS BLEACH ACTIVATORS AMERICAN CYANAMID COMPANY (US) 1976-10-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20260070884-A1 Inhibitors of Dihydroceramide Desaturase for Treating Disease CERS2, DEGS1, CERT1 KMT2A 3647/4885ATM 4778/4885CES2 87/4885
US-20040106629-A1 Compouds in the form of homodimeric, heterodimeric and/or homo and heteromultimeric pro-drugs; process for obtaining these pro-drugs and their acceptable pharmaceutical salts and use of compounds in the treatment of phosphodiesterasis-mediated deseases or dysfunction PEPD, PREP, PAPSS1 KMT2A 4493/4885ATM 4290/4885CES2 10/4885
US-20210130395-A1 PROXIMITY INDUCED SITE-SPECIFIC ANTIBODY CONJUGATION CD2BP2, FCGR2A, FCGR3B KMT2A 2673/4885ATM 2552/4885CES2 2247/4885
US-20250388592-A1 (AZA)SPIROHEPTANE DERIVATIVES FOR THE TREATMENT OF NEURODEGENERATIVE DISORDERS SNCA, CHRNA6, CHRNA5 KMT2A 2287/4885ATM 4122/4885CES2 1101/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.