Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.64 |
| ▸ | THRB | P10828 | 1/20 | 0.64 |
| ▸ | ATM | Q13315 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | NOS2 | P35228 | 2/20 | 0.53 |
| ▸ | NOS3 | P29474 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.51 |
| ▸ | CASP6 | P55212 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27458570 | 0.87 | L3MBTL1 (0.60) | L3MBTL1THRBATMKMT2AMEN1 | |
| SCHEMBL27726136 | 0.85 | GAA (0.63) | L3MBTL1THRBATMKMT2AMEN1 | |
| SCHEMBL16152211 | 0.85 | L3MBTL1 (0.62) | L3MBTL1THRBATMKMT2AMEN1 | |
| SCHEMBL6264941 | 0.85 | L3MBTL1 (0.62) | L3MBTL1THRBATMKMT2AMEN1 | |
| SCHEMBL12184256 | 0.84 | THRB (0.54) | L3MBTL1THRBATMKMT2AMEN1 | |
| SCHEMBL12184203 | 0.83 | L3MBTL1 (0.60) | L3MBTL1THRBATMKMT2AMEN1 | |
| SCHEMBL1487940 | 0.82 | THRB (0.68) | L3MBTL1THRBATMKMT2AMEN1 | |
| SCHEMBL1487944 | 0.82 | THRB (0.68) | L3MBTL1THRBATMKMT2AMEN1 | |
| SCHEMBL23042307 | 0.82 | L3MBTL1 (0.59) | L3MBTL1THRBATMKMT2AMEN1 | |
| SCHEMBL8223985 | 0.82 | HPGD (0.62) | L3MBTL1THRBATMKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2897940-B1 | HETEROCYCLIC COMPOUNDS, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE THEREOF AND PROCESSES FOR THE PREPARATION THEREOF | BOEHRINGER INGELHEIM INT (DE) | 2019-05-01 | — | — | EP | disclosed |
| EP-2629771-B1 | USE OF PI3K INHIBITORS FOR THE TREATMENT OF OBESITY, STEATOSIS AND AGEING | FUNDACION CENTRO NAC DE INVESTIGACIONES ONCOLOGICAS CARLOS III (ES) | 2018-08-08 | — | — | EP | disclosed |
| US-8778935-B2 | Imidazopyrazines for use as kinase inhibitors | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2014-07-15 | — | — | US | disclosed |
| WO-2014044849-A1 | HETEROCYCLIC COMPOUNDS, MEDICAMENTS CONTAINING SAID COMPOUNDS, USE THEREOF AND PROCESSES FOR THE PREPARATION THEREOF | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2014-03-27 | — | — | WO | disclosed |
| WO-2011142359-A1 | SPIRO COMPOUND AND DRUG FOR ACTIVATING ADIPONECTIN RECEPTOR | 日産化学工業株式会社 (JP) | 2011-11-17 | — | — | WO | disclosed |
| US-7598244-B2 | [1,2,4]triazolo[1,5,a]pyrimidin-2-ylurea derivative and use thereof | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2009-10-06 | — | — | US | disclosed |
| US-7598244-B2 | [1,2,4]triazolo[1,5,a]pyrimidin-2-ylurea derivative and use thereof | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2009-10-06 | — | — | US | disclosed |
| US-20070078146-A1 | Antiinflamamtory agents; antiarthritic agents; inflammatory bowel disorders; multiple sclerosis; asthma | PHARMACIA CORPORATION | 2007-04-05 | — | — | US | disclosed |
| US-20070010515-A1 | [1,2,4] Triazolo [1,5, a] pyrimidin-2-ylurea derivative and use thereof | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2007-01-11 | — | — | US | disclosed |
| US-20070010515-A1 | [1,2,4] Triazolo [1,5, a] pyrimidin-2-ylurea derivative and use thereof | NIPPON KAYAKU KABUSHIKI KAISHA (JP) | 2007-01-11 | — | — | US | disclosed |
| EP-0892802-B1 | SPIRO(CYCLOPENT(B)INDOLE-PIPERIDINES) AND N-PHENYL-HYDRAZON INTERMEDIATES FOR THEIR PREPARATION, BOTH BEING ACETYLCHOLINESTERASE AND MAO INHIBITORS | AVENTIS PHARMA INC (US) | 2003-10-22 | — | — | EP | disclosed |
| US-6479501-B2 | COGNITION ACTIVATORS; ANTIDEPRESSANTS | AVENTIS PHARMACEUTICALS INC. | 2002-11-12 | — | — | US | disclosed |
| US-20020004601-A1 | Spiro[cyclopent[b]indole-piperidines] | HOECHST MARION ROUSSEL, INC. | 2002-01-10 | — | — | US | disclosed |
| US-6229014-B1 | 8-AZASPIRO(4.5)DECANE-1-ONE; ANTIDEPRESSANTS AND TREATMENT OF PSYCHOLIGICAL DISORDERS, SPECIFICALLY MEMORY LOSS | HOECHST MARION ROUSSEL, INC. (FR) | 2001-05-08 | — | — | US | disclosed |
| US-6156901-A | Spiro[cyclopent[b]indole-piperidines] | HOECHST MARION ROUSSEL, INC. (US) | 2000-12-05 | — | — | US | disclosed |
| US-5986097-A | ENANTIOMORPHS, COGNITION ACTIVATORS, AZHEIMER'S DISEASE AND ENZYME INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-11-16 | — | — | US | disclosed |
| EP-0892802-A1 | SPIRO(CYCLOPENT(B)INDOLE-PIPERIDINES) AND N-PHENYL-HYDRAZON INTERMEDIATES FOR THEIR PREPARATION, BOTH BEING ACETYLCHOLINESTERASE AND MAO INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1999-01-27 | — | — | EP | disclosed |
| US-5756743-A | USEFUL IN TREATING MEMORY DYSFUNCTION AND DEPRESSION | HOECHST MARION ROUSSEL INC. (US) | 1998-05-26 | — | — | US | disclosed |
| WO-1997037992-A2 | SPIRO[CYCLOPENT[B]INDOLE-PIPERIDINES] AND N-PHENYL-HYDRAZON INTERMEDIATES FOR THEIR PREPARATION, BOTH BEING ACETYLCHOLINESTERASE AND MAO INHIBITORS | HOECHST MARION ROUSSEL, INC. (US) | 1997-10-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010515-A1 | [1,2,4] Triazolo [1,5, a] pyrimidin-2-ylurea derivative and use thereof | HLA-C, TPMT, TAP1 | L3MBTL1 1326/4885THRB 3686/4885ATM 2828/4885 |
| US-20070078146-A1 | Antiinflamamtory agents; antiarthritic agents; inflammatory bowel disorders; multiple sclerosis; asthma | MAPK1, MAPK3, MAPK4 | L3MBTL1 2366/4885THRB 3877/4885ATM 1342/4885 |
| US-20020004601-A1 | Spiro[cyclopent[b]indole-piperidines] | CAMK2B, GRIN2B, HTR2B | L3MBTL1 3519/4885THRB 121/4885ATM 2604/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.