Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 6/20 | 0.55 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.38 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.38 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.38 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.38 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6961034 | 0.88 | GRIN2B (0.57) | GRIN2BGRIN1LMNATSHRHIF1A | |
| SCHEMBL6970991 | 0.80 | GRIN2B (0.51) | GRIN2BGRIN1HTR3AHTR3EHTR3B | |
| SCHEMBL6970727 | 0.77 | PRSS1 (0.56) | PRSS1PRSS2PRSS3 | |
| SCHEMBL6973014 | 0.76 | GRIN2B (0.55) | GRIN2BGRIN1 | |
| SCHEMBL6969101 | 0.74 | MPO (0.40) | PRSS1PRSS2PRSS3SMN1; SMN2RAB9A | |
| SCHEMBL8622924 | 0.72 | HRH3 (0.54) | GRIN2BGRIN1LMNATSHRHIF1A | |
| SCHEMBL649075 | 0.72 | ALDH1A1 (0.46) | LMNATSHRADRA2ACYP2D6ADRA2B | |
| SCHEMBL2102562 | 0.71 | HRH3 (0.51) | TDP1SMN1; SMN2L3MBTL1RAB9AHRH3 | |
| SCHEMBL31060957 | 0.71 | HRH3 (0.55) | CYP2D6HRH4HRH3 | |
| SCHEMBL2105133 | 0.70 | PNMT (0.43) | HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729459-B1 | PHENYL-ALKYL IMIDAZOLES AS H3-RECEPTOR ANTAGONISTS | SCHERING CORP (US) | 2003-03-12 | — | — | EP | disclosed |
| US-5578616-A | ANTIINFLAMMATORY AGENTS, ANTIALLERGENS, TREATMENT FOR GASTROINTESTINAL AND CARDIOVASCULAR DISORDERS | SCHERING CORPORATION (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0729459-A1 | PHENYL-ALKYL IMIDAZOLES AS H3-RECEPTOR ANTAGONISTS | SCHERING CORPORATION (US) | 1996-09-04 | — | — | EP | disclosed |
| WO-1995014007-A1 | PHENYL-ALKYL IMIDAZOLES AS H3-RECEPTOR ANTAGONISTS | SCHERING CORPORATION (US) | 1995-05-26 | — | — | WO | disclosed |