Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | GLA | P06280 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | FLT1 | P17948 | 1/20 | 0.40 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | CASP7 | P55210 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6969357 | 0.84 | ALOX5 (0.46) | ALOX5KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL6965767 | 0.80 | L3MBTL1 (0.46) | KDM4EALDH1A1MAPTHPGDGLA | |
| SCHEMBL6957890 | 0.80 | KDM4E (0.41) | ALOX5KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL17468787 | 0.79 | ALOX5 (0.51) | ALOX5KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL9566160 | 0.77 | ALOX5 (0.50) | ALOX5KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL14354674 | 0.75 | HSP90AB1 (0.56) | KDM4EALDH1A1MAPTHPGDGLA | |
| SCHEMBL9566169 | 0.71 | ALOX5 (0.43) | ALOX5KDM4EALDH1A1MAPTHPGD | |
| SCHEMBL769393 | 0.71 | PDGFRB (0.50) | KDM4EALDH1A1MAPTHPGDGLA | |
| SCHEMBL3031292 | 0.71 | — | — | |
| SCHEMBL26650752 | 0.71 | KDM4E (0.46) | KDM4EALDH1A1MAPTHPGDGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1329160-A2 | 4-ACYLAMINOPYRAZOLE DERIVATIVES | Sankyo Company, Limited (JP) | 2003-07-23 | — | — | EP | disclosed |