Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | LIPE | Q05469 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.37 |
| ▸ | MTTP | P55157 | 4/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.36 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8472959 | 0.87 | ABCB1 (0.39) | POLBESR1ESR2NPC1RAB9A | |
| SCHEMBL8474716 | 0.87 | ABCB1 (0.47) | ESR1ESR2NPC1RAB9ALIPE | |
| SCHEMBL8470892 | 0.85 | ABCB1 (0.42) | ESR1ESR2NPC1RAB9AALDH1A1 | |
| SCHEMBL8582518 | 0.85 | ESR1 (0.44) | ESR1ESR2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8475640 | 0.85 | MTTP (0.39) | ESR1ESR2ALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8472958 | 0.85 | SMO (0.43) | ESR1ESR2RAB9ALMNALIPE | |
| SCHEMBL8473577 | 0.84 | HPGD (0.42) | POLBESR1ESR2RAB9AALDH1A1 | |
| SCHEMBL8471797 | 0.84 | ESR1 (0.43) | ESR1ESR2ALDH1A1LMNALIPE | |
| SCHEMBL6969388 | 0.84 | MTTP (0.51) | NPC1RAB9AALDH1A1LMNASMN1; SMN2 | |
| SCHEMBL8472074 | 0.84 | CHRNB2 (0.45) | ESR1ESR2ALDH1A1SMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919795-A | ATHEROSCLEROSIS THERAPY | PFIZER INC. (US) | 1999-07-06 | — | — | US | claimed |
| US-5919795-A | ATHEROSCLEROSIS THERAPY | PFIZER INC. (US) | 1999-07-06 | — | — | US | disclosed |