Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MPO | P05164 | 3/20 | 0.58 |
| ▸ | HTR1D | P28221 | 10/20 | 0.56 |
| ▸ | HTR1B | P28222 | 10/20 | 0.56 |
| ▸ | HTR2A | P28223 | 4/20 | 0.54 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6969558 | 0.81 | MPO (0.60) | MPOHTR1DHTR1BHTR2ABRD4 | |
| SCHEMBL6967767 | 0.80 | HTR1D (0.59) | MPOHTR1DHTR1BHTR2ABRD4 | |
| SCHEMBL6966135 | 0.79 | MPO (0.57) | MPOHTR1DHTR1BHTR2ABRD4 | |
| SCHEMBL6965752 | 0.78 | HTR1A (0.59) | MPOHTR1DHTR1BHTR2AHTR7 | |
| SCHEMBL6967771 | 0.77 | MPO (0.55) | MPOHTR1DHTR1BHTR2ABRD4 | |
| SCHEMBL27095364 | 0.76 | HTR7 (0.71) | MPOHTR1DHTR1BHTR2AHTR7 | |
| SCHEMBL26989598 | 0.75 | HTR7 (0.70) | MPOHTR1DHTR1BHTR2AHTR7 | |
| SCHEMBL6968414 | 0.75 | DRD3 (0.56) | MPOHTR1DHTR1BHTR2AHTR2C | |
| SCHEMBL8506914 | 0.74 | HTR1D (0.71) | MPOHTR1DHTR1BHTR2ABRD4 | |
| SCHEMBL733997 | 0.74 | MPO (1.00) | MPOHTR1DHTR1BHTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1289479-C | As 5-HT1D5-ring indole compounds of receptor ligands | ALLELIX BIOPHARMA (CA) | 2006-12-13 | — | — | CN | claimed |
| EP-0944595-B1 | 5-CYCLO INDOLE COMPOUNDS AS 5-HT1D RECEPTOR LIGANDS | NPS ALLELIX CORP (CA) | 2003-10-01 | — | — | EP | claimed |
| CN-1245491-A | 5-cyclo indole compounds as 5-HT receptor ligands | ALLELIX BIOPHARMA (CA) | 2000-02-23 | — | — | CN | claimed |
| US-5998438-A | SEROTONIN RECEPTOR ANTAGONIST; HEADACHE THERAPY | ALLELIX BIOPHARMACEUTICALS, INC. (CA) | 1999-12-07 | — | — | US | claimed |
| CN-1289479-C | As 5-HT1D5-ring indole compounds of receptor ligands | ALLELIX BIOPHARMA (CA) | 2006-12-13 | — | — | CN | disclosed |
| EP-0944595-B1 | 5-CYCLO INDOLE COMPOUNDS AS 5-HT1D RECEPTOR LIGANDS | NPS ALLELIX CORP (CA) | 2003-10-01 | — | — | EP | disclosed |
| CN-1245491-A | 5-cyclo indole compounds as 5-HT receptor ligands | ALLELIX BIOPHARMA (CA) | 2000-02-23 | — | — | CN | disclosed |
| US-5998438-A | SEROTONIN RECEPTOR ANTAGONIST; HEADACHE THERAPY | ALLELIX BIOPHARMACEUTICALS, INC. (CA) | 1999-12-07 | — | — | US | disclosed |