Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.40 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.40 |
| ▸ | SLC6A11 | P48066 | 1/20 | 0.40 |
| ▸ | SLC6A13 | Q9NSD5 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.39 |
| ▸ | EBP | Q15125 | 2/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | EBPL | Q9BY08 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6197260 | 0.88 | ADRA1A (0.42) | HTR7SLC6A1SLC6A12SLC6A11SLC6A13 | |
| SCHEMBL7225736 | 0.87 | HTR2A (0.42) | HTR7SLC6A1SLC6A12SLC6A11SLC6A13 | |
| SCHEMBL6969857 | 0.84 | DRD3 (0.43) | ADRA1ASIGMAR1DRD3 | |
| SCHEMBL7079236 | 0.81 | DRD2 (0.57) | ADRA1ASIGMAR1DRD3DRD2 | |
| SCHEMBL7234932 | 0.80 | DRD2 (0.42) | HTR7SLC6A1SLC6A12SLC6A11SLC6A13 | |
| SCHEMBL6963314 | 0.80 | HTR2A (0.44) | HTR7SLC6A1SLC6A12SLC6A11SLC6A13 | |
| SCHEMBL6199339 | 0.76 | DRD2 (0.45) | HTR7ADRA1ASIGMAR1EBPTMEM97 | |
| SCHEMBL6195779 | 0.76 | SIGMAR1 (0.57) | HTR7ADRA1ASIGMAR1CYP2D6 | |
| SCHEMBL6196180 | 0.76 | HSD17B10 (0.57) | HTR7SLC6A1SLC6A12SLC6A11ADRA1A | |
| Hydrochloric Acid SCHEMBL6967332 | 0.75 | OPRM1 (0.49) | SIGMAR1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6620815-B1 | Selective antagonists for human alpha 1A receptors; benign prostatic hyperplasia, impotency, cardiac arrhythmia treatment; anticholesterol agents; intraocular pressure reduction | SYNAPTIC PHARMACEUTICAL CORPORATION | 2003-09-16 | — | — | US | disclosed |
| EP-0988295-A4 | HETEROCYCLIC SUBSTITUTED PIPERIDINES AND USES THEREOF | SYNAPTIC PHARMA CORP (US) | 2003-08-13 | — | — | EP | disclosed |
| US-6159990-A | Oxazolidinones as α1A receptor antagonists | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-12-12 | — | — | US | disclosed |
| EP-0988295-A1 | HETEROCYCLIC SUBSTITUTED PIPERIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 2000-03-29 | — | — | EP | disclosed |
| WO-1998057940-A1 | HETEROCYCLIC SUBSTITUTED PIPERIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1998-12-23 | — | — | WO | disclosed |