Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 14/20 | 0.64 |
| ▸ | SLC6A4 | P31645 | 11/20 | 0.53 |
| ▸ | MPO | P05164 | 3/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.47 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.47 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.46 |
| ▸ | HTR3B | O95264 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR1E | P28566 | 1/20 | 0.46 |
| ▸ | HTR1F | P30939 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | HTR3A | P46098 | 1/20 | 0.46 |
| ▸ | HTR5A | P47898 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6971407 | 0.80 | HTR1A (0.90) | HTR1ASLC6A4MPOHTR2A | |
| SCHEMBL7820619 | 0.71 | HTR1A (0.64) | HTR1ASLC6A4MPOHTR7 | |
| SCHEMBL24497000 | 0.70 | SLC6A4 (1.00) | HTR1ASLC6A4MPOHTR3EHTR3B | |
| SCHEMBL5432392 | 0.70 | HTR1A (1.00) | HTR1ASLC6A4 | |
| Hydrochloric Acid SCHEMBL5794689 | 0.69 | HTR1A (0.98) | HTR1ASLC6A4 | |
| SCHEMBL7825328 | 0.68 | HTR1A (0.66) | HTR1ASLC6A4MPOHTR2A | |
| SCHEMBL7818055 | 0.68 | SLC6A4 (0.58) | HTR1ASLC6A4SLC6A2SLC6A3HTR3E | |
| SCHEMBL1968664 | 0.66 | HTR1A (0.72) | HTR1ASLC6A4SLC6A2SLC6A3HTR3E | |
| SCHEMBL30419697 | 0.66 | HTR2A (0.67) | HTR1ASLC6A4SLC6A2SLC6A3HTR3E | |
| SCHEMBL25282274 | 0.66 | HTR2A (0.67) | HTR1ASLC6A4SLC6A2SLC6A3HTR3E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140925-B1 | (3,4 DIHYDRO-2H-BENZO[1,4] OXAZINYL-METHYL)- 3-(1H-INDOL-3- YL)-ALKYL -AMINES | WYETH CORP (US) | 2003-04-23 | — | — | EP | claimed |
| US-6313114-B1 | ANTIDEPRESSANTS | AMERICAN HOME PRODUCTS CORP | 2001-11-06 | — | — | US | claimed |
| EP-1140925-A1 | (3,4 DIHYDRO-2H-BENZO[1,4] OXAZINYL-METHYL)- 3-(1H-INDOL-3- YL)-ALKYL -AMINES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2001-10-10 | — | — | EP | claimed |
| WO-2000040580-A1 | 3,4-DIHYDRO-2H-BENZO[1,4]OXAZINYL-METHYL[3-(1H-INDOL-3-YL)-ALKYL]-AMINES | AMERICAN HOME PRODUCTS CORPORATION (US) | 2000-07-13 | — | — | WO | claimed |