Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 3/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 5/20 | 0.31 |
| ▸ | MEN1 | O00255 | 4/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | XBP1 | P17861 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.31 |
| ▸ | XDH | P47989 | 1/20 | 0.31 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.30 |
| ▸ | TMPRSS4 | Q9NRS4 | 1/20 | 0.30 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17843544 | 0.81 | KIF11 (0.36) | GABRA1GABRB2MAPTMEN1KMT2A | |
| SCHEMBL4218723 | 0.79 | HTR3E (0.36) | GABRA1GABRB2MAPTMEN1KMT2A | |
| SCHEMBL4222270 | 0.79 | GABRA1 (0.35) | GABRA1GABRB2MAPTMEN1KMT2A | |
| SCHEMBL21175883 | 0.75 | GABRA1 (0.35) | GABRA1GABRB2MAPTMEN1KMT2A | |
| SCHEMBL1987173 | 0.74 | GABRA1 (0.38) | GABRA1GABRB2MAPTMEN1KMT2A | |
| SCHEMBL19828710 | 0.72 | GAA (0.34) | GABRA1GABRB2MAPTMEN1KMT2A | |
| Phenol SCHEMBL17260915 | 0.72 | CLCN2 (0.33) | GABRA1GABRB2MAPTMEN1KMT2A | |
| SCHEMBL19511725 | 0.71 | KDM4E (0.40) | GABRA1GABRB2MAPTMEN1KMT2A | |
| SCHEMBL17974429 | 0.71 | XDH (0.42) | GABRA1GABRB2MAPTMEN1KMT2A | |
| SCHEMBL2299901 | 0.70 | XDH (0.43) | GABRA1GABRB2MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6638936-B1 | Treatment of obesity in mammals, comprising administering to mammal in need of such treatment, treatment of obsessive compulsive disorder in mammals, comprising administering to a mammal treatment of depression in mammals | ELI LILLY AND COMPANY | 2003-10-28 | — | — | US | disclosed |
| EP-1204658-B1 | BENZOFURYLPIPERAZINE SEROTONIN AGONISTS | LILLY CO ELI (US) | 2003-05-07 | — | — | EP | disclosed |
| EP-1204658-A1 | BENZOFURYLPIPERAZINE SEROTONIN AGONISTS | ELI LILLY AND COMPANY (US) | 2002-05-15 | — | — | EP | disclosed |
| WO-2001009123-A1 | BENZOFURYLPIPERAZINE SEROTONIN AGONISTS | ELI LILLY AND COMPANY (US) | 2001-02-08 | — | — | WO | disclosed |