SCHEMBL6970028

SCHEMBL6970028

CCC(OCCO)c1nc(Sc2cccc([N+](=O)[O-])c2)c(C(C)C)[nH]1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.34
CYP2D6 P10635 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
RECQL P46063 1/20 0.33
CACNA1C Q13936 4/20 0.33
MEN1 O00255 3/20 0.32
KMT2A Q03164 3/20 0.32
KDM4E B2RXH2 1/20 0.32
ATM Q13315 1/20 0.32
MAOA P21397 4/20 0.32
MAOB P27338 4/20 0.32
MAPT P10636 2/20 0.32
HPGD P15428 2/20 0.32
ALDH1A1 P00352 1/20 0.32
LMNA P02545 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
USP2 O75604 1/20 0.31
POLB P06746 1/20 0.31
HTT P42858 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6966070 0.90 HSP90AA1 (0.36) HSP90AA1CYP2D6CYP2C9CYP2C19RECQL
SCHEMBL6961323 0.88 PDE4B (0.35) HSP90AA1CYP2D6CYP2C9CYP2C19RECQL
SCHEMBL6974133 0.86 CACNA1C (0.36) HSP90AA1CYP2D6CYP2C9CYP2C19RECQL
SCHEMBL6971992 0.85 HSP90AA1 (0.34) HSP90AA1CYP2D6CYP2C9CYP2C19RECQL
SCHEMBL7084551 0.84 SLC6A9 (0.33)
SCHEMBL6960607 0.84 ALOX12 (0.36) CYP2C9CYP2C19MEN1KMT2AKDM4E
SCHEMBL7085331 0.84 HSP90AA1 (0.39) HSP90AA1CACNA1CMEN1KMT2AKDM4E
SCHEMBL6961650 0.83 ALDH1A1 (0.31) ALDH1A1POLB
SCHEMBL7079832 0.81 HSP90AA1 (0.43) HSP90AA1MEN1KMT2AMAOAMAOB
SCHEMBL7084668 0.78 HSP90AA1 (0.38) HSP90AA1CYP2D6CYP2C9CYP2C19RECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786455-B1 IMIDAZOLE DERIVATIVE SHIONOGI & CO (JP) 2003-12-03 EP disclosed
US-6147097-A METHOD FOR TREATING AIDS SHIONOGI & CO., LTD. (JP) 2000-11-14 US disclosed
US-5910506-A IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC SHIONOGI & CO., LTD. (JP) 1999-06-08 US disclosed
EP-0786455-A1 IMIDAZOLE DERIVATIVE SHIONOGI & CO., LTD. (JP) 1997-07-30 EP disclosed