SCHEMBL7085331

SCHEMBL7085331

CCC(O)c1nc(Sc2cccc([N+](=O)[O-])c2)c(C(C)C)[nH]1

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSP90AA1 P07900 1/20 0.39
MEN1 O00255 4/20 0.38
KMT2A Q03164 4/20 0.38
HPGD P15428 3/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
KDM4E B2RXH2 1/20 0.35
USP2 O75604 1/20 0.35
POLB P06746 1/20 0.35
MAOA P21397 4/20 0.35
MAOB P27338 4/20 0.35
MAPT P10636 3/20 0.35
ALDH1A1 P00352 3/20 0.35
SMN1; SMN2 Q16637 3/20 0.35
LMNA P02545 1/20 0.35
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
RIPK1 Q13546 1/20 0.34
HTT P42858 1/20 0.34
CACNA1C Q13936 1/20 0.34
PKM P14618 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7079832 0.89 HSP90AA1 (0.43) HSP90AA1MEN1KMT2AHPGDL3MBTL1
SCHEMBL6968078 0.87 ALOX5 (0.38) HSP90AA1MEN1KMT2AHPGDL3MBTL1
SCHEMBL6974133 0.84 CACNA1C (0.36) HSP90AA1MEN1KMT2AHPGDKDM4E
SCHEMBL6970028 0.84 HSP90AA1 (0.34) HSP90AA1MEN1KMT2AHPGDKDM4E
SCHEMBL6975315 0.83 HSP90AA1 (0.39) HSP90AA1MEN1KMT2AHPGDL3MBTL1
SCHEMBL6966070 0.82 HSP90AA1 (0.36) HSP90AA1MEN1KMT2AHPGDUSP2
SCHEMBL7084668 0.82 HSP90AA1 (0.38) HSP90AA1MEN1KMT2AHPGDMAOA
SCHEMBL7087098 0.81 TP53 (0.39) MEN1KMT2AHPGDKDM4EPOLB
SCHEMBL6969392 0.81 CA2 (0.36)
SCHEMBL6967049 0.81 LMNA (0.37) KMT2AL3MBTL1KDM4EPOLBMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0786455-B1 IMIDAZOLE DERIVATIVE SHIONOGI & CO (JP) 2003-12-03 EP disclosed
US-6147097-A METHOD FOR TREATING AIDS SHIONOGI & CO., LTD. (JP) 2000-11-14 US disclosed
US-5910506-A IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC SHIONOGI & CO., LTD. (JP) 1999-06-08 US disclosed
EP-0786455-A1 IMIDAZOLE DERIVATIVE SHIONOGI & CO., LTD. (JP) 1997-07-30 EP disclosed