Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.61 |
| ▸ | F2 | P00734 | 1/20 | 0.61 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aminodiphenylmethane SCHEMBL7841 | 0.97 | DPP4 (0.65) | DPP4F2HTR2ATAAR1ADRA2A | |
| Aminodiphenylmethane SCHEMBL2408346 | 0.93 | DPP4 (0.61) | DPP4F2HTR2ATAAR1ADRA2A | |
| Aminodiphenylmethane SCHEMBL1764753 | 0.93 | DPP4 (0.61) | DPP4F2HTR2ATAAR1ADRA2A | |
| Aminodiphenylmethane SCHEMBL28527476 | 0.93 | DPP4 (0.61) | DPP4F2HTR2ATAAR1ADRA2A | |
| Aminodiphenylmethane SCHEMBL9596876 | 0.93 | DPP4 (0.61) | DPP4F2HTR2ATAAR1ADRA2A | |
| SCHEMBL11480062 | 0.93 | DPP4 (0.61) | DPP4F2HTR2ATAAR1ADRA2A | |
| Aminodiphenylmethane SCHEMBL8518249 | 0.93 | DPP4 (0.61) | DPP4F2HTR2ATAAR1ADRA2A | |
| Aminodiphenylmethane SCHEMBL8686295 | 0.93 | DPP4 (0.61) | DPP4F2HTR2ATAAR1ADRA2A | |
| SCHEMBL11478580 | 0.93 | DPP4 (0.61) | DPP4F2HTR2ATAAR1ADRA2A | |
| Aminodiphenylmethane SCHEMBL7719817 | 0.88 | DPP4 (0.55) | DPP4F2HTR2ATAAR1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863136-B1 | Derivatives of azetidine and pyrrolidine | AKZO NOBEL NV (NL) | 2003-09-24 | — | — | EP | disclosed |
| US-6403573-B1 | BICYCLIC-CARBO OR HETERO OXY OR BICYCLIC CARBO OR HETERO SULFIDE CONTAINING PYRROLIDINE/AZETIDINE DERIVATIVES USED AS ANTIDEPRESSANT OR PREVENTING SEROTONIN-RELATED DISEASES | AKZO NOBEL N.V. (NL) | 2002-06-11 | — | — | US | disclosed |
| US-20020040016-A1 | Derivatives of azetidine and pyrrolidine | MERCK SHARP & DOHME B.V. (NL) | 2002-04-04 | — | — | US | disclosed |
| US-6281243-B1 | ANTIDEPRESSANTS, ANTISEROTONINE AGENT | AKZO NOBEL N.V. (NL) | 2001-08-28 | — | — | US | disclosed |
| WO-1999043647-A1 | DERIVATIVES OF AZETIDINE AND PYRROLIDINE | AKZO NOBEL N.V. (NL) | 1999-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020040016-A1 | Derivatives of azetidine and pyrrolidine | TPH1, TPH2, HTR1D | DPP4 2928/4885F2 4216/4885HTR2A 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.