Known targets — ChEMBL curated mechanism
ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO
The experimentally established mechanism targets of Aminodiphenylmethane. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 known ✓ | P27487 | 2/20 | 0.61 |
| ▸ | HTR2A known ✓ | P28223 | 1/20 | 0.48 |
| ▸ | ADRA2A known ✓ | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.61 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Aminodiphenylmethane SCHEMBL7841 | 0.97 | DPP4 (0.65) | DPP4F2HTR2ATAAR1ADRA2A | |
| SCHEMBL11480062 | 0.93 | DPP4 (0.61) | DPP4F2HTR2ATAAR1ADRA2A | |
| Aminodiphenylmethane SCHEMBL6970159 | 0.93 | DPP4 (0.61) | DPP4F2HTR2ATAAR1ADRA2A | |
| Aminodiphenylmethane SCHEMBL28527476 | 0.93 | DPP4 (0.61) | DPP4F2HTR2ATAAR1ADRA2A | |
| SCHEMBL11478580 | 0.93 | DPP4 (0.61) | DPP4F2HTR2ATAAR1ADRA2A | |
| Aminodiphenylmethane SCHEMBL9596876 | 0.93 | DPP4 (0.61) | DPP4F2HTR2ATAAR1ADRA2A | |
| Aminodiphenylmethane SCHEMBL8686295 | 0.93 | DPP4 (0.61) | DPP4F2HTR2ATAAR1ADRA2A | |
| Aminodiphenylmethane SCHEMBL2408346 | 0.93 | DPP4 (0.61) | DPP4F2HTR2ATAAR1ADRA2A | |
| Aminodiphenylmethane SCHEMBL1764753 | 0.93 | DPP4 (0.61) | DPP4F2HTR2ATAAR1ADRA2A | |
| Aminodiphenylmethane SCHEMBL28037935 | 0.90 | DPP4 (0.58) | DPP4F2HTR2ATAAR1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115845913-B | Method for producing substituted aromatic hydrocarbon by alkylation, catalyst and preparation method thereof | 中国石油化工股份有限公司 | 2025-03-07 | — | — | CN | disclosed |
| CN-115869991-B | Benzene alkylation molecular sieve catalyst and preparation method and application thereof | 中国石油化工股份有限公司 | 2025-03-04 | — | — | CN | disclosed |
| CN-1755524-A | Photosensitive thermosetting resin composition, resist-coated printed wiring board, and method for producing same | YAMASAKA CHEMICAL CO LTD (JP) | 2006-04-05 | — | — | CN | disclosed |
| EP-0644215-B1 | Bis(N-alkylaminocyclohexyl)methanes as curing agents for polyurethanes and polyureas | UOP INC (US) | 1999-04-14 | — | — | EP | disclosed |
| EP-0644215-A1 | Bis(N-alkylaminocyclohexyl)methanes as curing agents for polyurethanes and polyureas | UOP (US) | 1995-03-22 | — | — | EP | disclosed |
| US-5312886-A | Chain extension of polyureas or polyurethanes | UOP (US) | 1994-05-17 | — | — | US | disclosed |
| US-4948861-A | N,N'-dialkylphenylenediamines as curing agents in polyurethane and polyurea manufacture by reaction injection molding | UOP (US) | 1990-08-14 | — | — | US | disclosed |
| US-4847347-A | MOLDING MATERIALS | UOP (US) | 1989-07-11 | — | — | US | disclosed |
| US-4806616-A | N-N'-dialkylphenylenediamines as curing agents in polyurethane and polyurea manufacture by reaction injection molding | UOP INC. (US) | 1989-02-21 | — | — | US | disclosed |
| US-4801674-A | ELASTOMERS | UOP INC. (US) | 1989-01-31 | — | — | US | disclosed |
| US-4736009-A | Partially alkylated triamines and higher polyamines as curing agents in polyurethane manufacture by reaction injection molding | UOP INC. (US) | 1988-04-05 | — | — | US | disclosed |
| US-4551502-A | Macromolecular complexes of amidocarbonylic water-soluble polymers and square platinous and equivalent organometallics | HOWELL BOBBY A | 1985-11-05 | — | — | US | disclosed |