Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | PAX8 | Q06710 | 3/20 | 0.50 |
| ▸ | F2 | P00734 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | BRPF1 | P55201 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | BRD4 | O60885 | 2/20 | 0.47 |
| ▸ | BRD1 | O95696 | 2/20 | 0.47 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.47 |
| ▸ | BRPF3 | Q9ULD4 | 2/20 | 0.47 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6978112 | 0.97 | F2 (0.49) | SMN1; SMN2PAX8F2RAB9ALMNA | |
| SCHEMBL6977191 | 0.89 | F2 (0.55) | SMN1; SMN2PAX8F2RAB9ALMNA | |
| SCHEMBL6637025 | 0.84 | PAX8 (0.64) | SMN1; SMN2PAX8F2RAB9ALMNA | |
| SCHEMBL8137693 | 0.84 | F2 (0.56) | SMN1; SMN2PAX8F2LMNABRPF1 | |
| SCHEMBL6637137 | 0.82 | GAA (0.44) | SMN1; SMN2PAX8LMNAALDH1A1MEN1 | |
| SCHEMBL6635412 | 0.81 | F2 (0.46) | SMN1; SMN2PAX8F2LMNABRPF1 | |
| SCHEMBL6978117 | 0.81 | TSHR (0.43) | F2RAB9ABRPF1ALDH1A1MEN1 | |
| SCHEMBL6634682 | 0.80 | LMNA (0.53) | SMN1; SMN2PAX8F2RAB9ALMNA | |
| SCHEMBL6977229 | 0.80 | TSHR (0.42) | SMN1; SMN2F2RAB9ABRPF1ALDH1A1 | |
| SCHEMBL6475543 | 0.78 | KDM4E (0.48) | SMN1; SMN2F2RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1220845-B1 | ARYL-SULFONAMIDE SUBSTITUTED BENZIMIDAZOL DERIVATIVES AND USE OF SAID AS TRYPTASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA (DE) | 2003-08-13 | — | — | EP | disclosed |
| EP-1220845-A1 | ARYL-SULFONAMIDE SUBSTITUTED BENZIMIDAZOL DERIVATIVES AND USE OF SAID AS TRYPTASE INHIBITORS | Boehringer Ingelheim Pharma KG (DE) | 2002-07-10 | — | — | EP | disclosed |
| US-6413990-B1 | ANTIINFLAMMATORY AGENTS, ANTIALLERGENS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-07-02 | — | — | US | disclosed |
| WO-2001023359-A1 | ARYL-SULFONAMIDE SUBSTITUTED BENZIMIDAZOL DERIVATIVES AND USE OF SAID AS TRYPTASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-04-05 | — | — | WO | disclosed |