Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | FERMT2 | Q96AC1 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | HTR1D | P28221 | 1/20 | 0.37 |
| ▸ | HTR1B | P28222 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | CA3 | P07451 | 1/20 | 0.35 |
| ▸ | CA6 | P23280 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1521870 | 0.84 | PKM (0.45) | MAPTMEN1HTTKMT2AALDH1A1 | |
| SCHEMBL3085200 | 0.83 | MAPT (0.46) | SMN1; SMN2MAPTMEN1HTTKMT2A | |
| SCHEMBL20207677 | 0.82 | SMN1; SMN2 (0.42) | SMN1; SMN2MAPTMEN1HTTKMT2A | |
| SCHEMBL19848697 | 0.81 | CHRNA7 (0.39) | SMN1; SMN2MAPTFERMT2CHRNA7PKM | |
| SCHEMBL3631150 | 0.81 | ALDH1A1 (0.42) | ALDH1A1LMNAFERMT2CHRNA7HTR1D | |
| SCHEMBL20376237 | 0.81 | IDO1 (0.35) | SMN1; SMN2MEN1KMT2AALDH1A1IDO1 | |
| SCHEMBL20201882 | 0.78 | CASR (0.41) | SMN1; SMN2MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL21324923 | 0.78 | TRPV1 (0.38) | MAPTALDH1A1HTR1DIDO1TRPA1 | |
| SCHEMBL18815188 | 0.77 | IDO1 (0.39) | MAPTALDH1A1FERMT2CHRNA7PKM | |
| SCHEMBL18893409 | 0.77 | KMT2A (0.41) | SMN1; SMN2MEN1KMT2ALMNACHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1021411-B1 | BENZAMIDE DERIVATIVES AS THROMBIN INHIBITORS | GLAXO GROUP LTD (GB) | 2003-03-05 | — | — | EP | disclosed |
| US-6326386-B1 | ANTICOAGULANT | GLAXO GROUP LIMITED (GB) | 2001-12-04 | — | — | US | disclosed |
| EP-1021411-A1 | BENZAMIDE DERIVATIVES AS THROMBIN INHIBITORS | GLAXO GROUP LIMITED (GB) | 2000-07-26 | — | — | EP | disclosed |
| WO-1997022589-A1 | BENZAMIDE DERIVATIVES AS THROMBIN INHIBITORS | GLAXO GROUP LIMITED (GB) | 1997-06-26 | — | — | WO | disclosed |